Honokiol decreases intra-abdominal adhesion formation in a rat model.

Abstract

AIM:

The purpose of this study was to investigate the effectiveness of honokiol, a natural molecule that was shown to have antioxidant effects, in prevention of intra-abdominal adhesion formation in a rat model.

MATERIAL AND METHOD:

This study was conducted on a total of 40 non-pregnant Sprague-Dawley rats, which were divided into 4 groups as follows: sham, control, saline, and honokiol groups. Both uterine horns of the rats in control, saline, and honokiol groups were exposed and a 2-cm segment of the anti-mesenteric surface of both uterine horns was traumatized by a scalpel. The saline group was administered 2 ml of saline/day intraperitoneally for 5 days after the operation. The honokiol group, on the other hand, was administered honokiol intraperitoneally at a dose of 1 mg/kg/day for 5 days after the operation. On postoperative day 14, 3 ml of intracardiac blood sample was taken from the rats for biochemical analyses, and the rats were sacrificed this way.

RESULTS:

Adhesion and inflammation scores were significantly lower in the honokiol group compared with the saline and control groups (p < 0.008). Similarly, fibrosis score was significantly lower in the honokiol group compared with the saline group (p < 0.008).

CONCLUSION:

Honokiol was found to be effective in prevention of intra-abdominal adhesion formation in a rat model. However, larger studies are needed to shed light on the exact role of honokiol in intra-abdominal adhesion formation and to determine the molecular aspects of the promising results found in this study.

• Authors: Elif Agacayak, Senem Yaman Tunc, Mehmet Sait Icen, Ulaş Alabalik, Fatih Mehmet Findik, Hatice Yuksel, Talip Gul
• Journal: Gynecologic and obstetric investigation (Gynecol Obstet Invest) Vol. 79 Issue 3 Pg. 160-7 ( 2015) ISSN: 1423-002X [Electronic] Switzerland
• PMID: 25632973 (Publication Type: Journal Article)
• Copyright: © 2015 S. Karger AG, Basel.

Chemical References

• Antioxidants
• Biphenyl Compounds
• Lignans
• honokiol

Topics

• Animals
• Antioxidants (pharmacology)
• Biphenyl Compounds (pharmacology)
• Disease Models, Animal
• Female
• Lignans (pharmacology)
• Postoperative Complications
• Rats
• Rats, Sprague-Dawley
• Tissue Adhesions (prevention & control)
• Uterus (surgery)