Rapid HIV progression during acute HIV-1 subtype C infection in a Mozambican patient with atypical seroconversion.

Abstract

Acute human immunodeficiency virus (HIV) infection (AHI) refers to the period between viral transmission and development of an adaptive immune response to HIV antigens (seroconversion) usually lasting 6-8 weeks. Rare cases have been described in which HIV-infected patients fail to seroconvert and instead, develop rapid HIV-mediated clinical decline. We report the case of a Mozambican woman with AHI and malaria coinfection who showed atypical seroconversion and experienced rapid deterioration and death within 14 weeks of diagnosis with AHI. Atypical seroconversion may be associated with rapid progression. Fourth generation rapid tests could lead to earlier identification and intervention for this vulnerable subgroup.

• Authors: Cesar Velasco, Erica Parker, Lucia Pastor, Abel Nhama, Salesio Macuacua, Inácio Mandomando, Julià Blanco, Denise Naniche
• Journal: The American journal of tropical medicine and hygiene (Am J Trop Med Hyg) Vol. 92 Issue 4 Pg. 681-3 (Apr 2015) ISSN: 1476-1645 [Electronic] United States
• PMID: 25624400 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © The American Society of Tropical Medicine and Hygiene.

Topics

• Acute Disease
• Adult
• Coinfection
• Disease Progression
• Fatal Outcome
• Female
• HIV Infections (complications, diagnosis, immunology, virology)
• HIV Seropositivity
• HIV-1 (immunology)
• Humans
• Malaria, Falciparum (complications, drug therapy)
• Mozambique