Prognostic significance of serum squamous cell carcinoma antigen in patients with head and neck cancer.
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| Abstract | CONCLUSIONS: Serum squamous cell carcinoma antigen (SCC-Ag) level was an independent prognostic factor for survival in patients with head and neck squamous cell carcinoma (HNSCC), and the prognostic value depended on the carcinoma site. OBJECTIVES: To assess the value of SCC-Ag as a prognostic indicator in patients with HNSCC and to determine the effect of primary tumor site on prognosis. METHODS: We reviewed 493 patients with HNSCC between 2004 and 2012. The chi-squared test was used to assess associations between SCC-Ag levels and TNM classification. A Cox proportional hazard model was used to assess the hazard ratio of SCC-Ag at different sites for death, and it was analyzed as a continuous variable. RESULTS: The median serum level of SCC-Ag was 1.1 ng/ml (range 0-20). SCC-Ag was significantly higher in patients with advanced T and N classification tumors. Primary sites in the oral cavity, in the hypopharynx, advanced T and N classification, distant metastasis, and SCC-Ag were negatively associated with survival in univariate analysis. Multivariate analysis revealed that SCC-Ag was a significant risk factor for overall survival in cancers of the oral cavity, hypopharynx, and larynx, but not in oropharyngeal cancer.
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| Authors | Ryusuke Imai, Yukinori Takenaka, Toshimichi Yasui, Susumu Nakahara, Yoshifumi Yamamoto, Atsushi Hanamoto, Norihiko Takemoto, Takahito Fukusumi, Hironori Cho, Masashi Yamamoto, Hidenori Inohara |
| Journal | Acta oto-laryngologica (Acta Otolaryngol) Vol. 135 Issue 3 Pg. 295-301 (Mar 2015) ISSN: 1651-2251 [Electronic] England |
| PMID | 25622661 (Publication Type: Journal Article) |
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