Abstract | OBJECTIVE: The current study marks the first randomized controlled trial to test the benefit of combining Seeking Safety (SS), a present-focused cognitive-behavioral therapy for co-occurring posttraumatic stress disorder ( PTSD) and alcohol use disorder (AUD), with sertraline, a front-line medication for PTSD shown to also impact drinking outcomes. METHOD: Sixty-nine participants (81% female; 59% African American) with primarily childhood sexual (46%) and physical (39%) trauma exposure, and drug dependence in addition to AUD were randomized to receive a partial-dose (12 sessions) of SS with either sertraline (n = 32; M = 7 sessions) or placebo (n = 37; M = 6 sessions). Assessments conducted at baseline, end-of-treatment, 6- and 12-months posttreatment measured PTSD and AUD symptom severity. RESULTS: Both groups demonstrated significant improvement in PTSD symptoms. The SS plus sertraline group exhibited a significantly greater reduction in PTSD symptoms than the SS plus placebo group at end-of-treatment (M difference = -16.15, p = .04, d = 0.83), which was sustained at 6- and 12-month follow-up (M difference = -13.81, p = .04, d = 0.71, and M difference = -12.72, p = .05, d = 0.65, respectively). Both SS groups improved significantly on AUD severity at all posttreatment time points with no significant differences between SS plus sertraline and SS plus placebo. CONCLUSION: Results support the combining of a cognitive-behavioral therapy and sertraline for PTSD/AUD. Clinically significant reductions in both PTSD and AUD severity were achieved and sustained through 12-months follow-up, Moreover, greater mean improvement in PTSD symptoms was observed across all follow-up assessments in the SS plus sertraline group. (PsycINFO Database Record
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Authors | Denise A Hien, Frances Rudnick Levin, Lesia M Ruglass, Teresa López-Castro, Santiago Papini, Mei-Chen Hu, Lisa Renee Cohen, Abigail Herron |
Journal | Journal of consulting and clinical psychology
(J Consult Clin Psychol)
Vol. 83
Issue 2
Pg. 359-69
(Apr 2015)
ISSN: 1939-2117 [Electronic] United States |
PMID | 25622199
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | (c) 2015 APA, all rights reserved). |
Chemical References |
- Serotonin Uptake Inhibitors
- Sertraline
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Topics |
- Adult
- Alcohol-Related Disorders
(drug therapy, psychology, therapy)
- Cognitive Behavioral Therapy
- Combined Modality Therapy
- Female
- Humans
- Male
- Middle Aged
- Selective Serotonin Reuptake Inhibitors
(therapeutic use)
- Sertraline
(therapeutic use)
- Stress Disorders, Post-Traumatic
(drug therapy, psychology, therapy)
- Treatment Outcome
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