[Hypogonadotropic hypogonadism in Klinefelter syndrome and hypothalamic-pituitary tumor].

Abstract

Klinefelter Syndrome is the most frequent cause of hypergonadotropic hypogonadism in men. A flat response at luteinizing hormone releasing hormone stimulation test could be the first sign of hypothalamic tumor in these patients. We report the case of a patient diagnosed by neonatal screening with Klinefelter Syndrome, 47 XXY, that at 17 years follow-up presents analytical modification of the response to luteinizing hormone releasing hormone stimulation test with suppressed luteinizing hormone and follicle-stimulating hormone values; lately he presents with headache and loss of left eye vision. A magnetic resonance imaging of the brain showed a mixed germ cell hypothalamus tumor, requiring surgery, chemotherapy and radiotherapy with optimal response.

• Authors: Anunciación Beisti Ortego, Antonio De Arriba Muñoz, Marta Ferrer Lozano, José Miguel Martínez de Zabarte Fernández, Carlota Calvo Escribano, José Ignacio Labarta Aizpún
• Journal: Archivos argentinos de pediatria (Arch Argent Pediatr) Vol. 113 Issue 1 Pg. e6-9 (Jan 2015) ISSN: 1668-3501 [Electronic] Argentina
• Vernacular Title: Hipogonadismo hipogonadotropo en paciente con síndrome de Klinefelter y tumor hipotálamo-hipofisario.
• PMID: 25622177 (Publication Type: Case Reports, Journal Article)

Topics

• Adolescent
• Humans
• Hypogonadism (etiology, therapy)
• Hypothalamic Neoplasms (complications, therapy)
• Klinefelter Syndrome (complications)
• Male
• Pituitary Neoplasms (complications, therapy)