[Ultrastructural and immunoelectron microscopic study of the desmoplastic stroma in carcinoma of the breast].

Abstract

Different collagen types (I, III, IV, V) were identified in breast carcinoma desmoplastic tissue by ultrastructural analysis and immunoelectronmicroscopy. Type V collagen is present as a 12 nm. fibril in the stroma, either adjacent to the basement membrane or concentrated around the thicker fibers. Myofibroblasts, fibroblasts and tumor cells can be its major producers. Its possible function as a bridge between different collagens can be utilized, with different finality, by the same cells that have produced it. Furthermore, type V collagen can be involved in tumor invasion of the stroma and in all directional movements of tumor cells, as already demonstrated for other extracellular matrix components.

• Authors: A Modesti, G D'Orazi, S Scarpa, S Mezi, F Gatti, G Aloise, D Gerace, P Guglielmi, L Simonelli, M Modesti
• Journal: Il Giornale di chirurgia (G Chir) Vol. 10 Issue 5 Pg. 245-9 (May 1989) ISSN: 0391-9005 [Print] Italy
• Vernacular Title: Studio ultrastrutturale ed immunoelettromicroscopico dello stroma desmoplastico nel carcinoma della mammella.
• PMID: 2562045 (Publication Type: English Abstract, Journal Article)

Chemical References

• Collagen

Topics

• Breast Neoplasms (chemistry, ultrastructure)
• Carcinoma, Intraductal, Noninfiltrating (chemistry, ultrastructure)
• Collagen (analysis)
• Fibrosis
• Humans
• Microscopy, Immunoelectron