Amphotericin B deoxycholate nasal spray administered to hematopoietic stem cell recipients with prior fungal colonization of the upper airway passages is associated with low rates of invasive fungal infection.
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| Abstract | BACKGROUND:
Invasive fungal infections cause major problems during hematopoietic stem cell transplantation (HSCT). Fungal colonization of the upper airway passages occurs frequently, and may serve as a portal of entry for potentially life-threatening fungal infections, especially in immunocompromised patients. METHODS: A clinical practice was instituted at Northwestern Memorial Hospital in Chicago in 2005, to administer amphotericin B deoxycholate nasal spray (ABNS) 0.5% to all HSCT recipients with fungal colonization of their nasal passages, in addition to standard oral antifungal prophylaxis. RESULTS: Among 1945 HSCT patients treated during the study period, 109 patients were identified with positive fungal surveillance cultures. CONCLUSION: Breakthrough fungal infections occurred in only 2 patients (2%), thus in this select group of HSCT recipients, ABNS administration is associated with a very low rate of breakthrough infection.
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| Authors | S M Trifilio, R Heraty, A Zomas, Z Zhou, J L Fong, D Liu, C Zhao, J Zhang, J Mehta |
| Journal | Transplant infectious disease : an official journal of the Transplantation Society (Transpl Infect Dis) Vol. 17 Issue 1 Pg. 1-6 (Feb 2015) ISSN: 1399-3062 [Electronic] Denmark |
| PMID | 25620386 (Publication Type: Journal Article) |
| Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
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