Expression of MUC1 and CD176 (Thomsen-Friedenreich antigen) in papillary thyroid carcinomas.

Abstract

The incidence of thyroid cancer has appeared as an increasing trend globally, especially in Asian countries. In this study, the expression of mucin-1 (MUC1) and Thomsen-Friedenreich antigen, Galβ1-3GalNAcα1-R (CD176) was investigated by immunohistochemistry in papillary thyroid carcinomas (PTCs), which accounts for approximately 80 % of all thyroid cancer. We found that 78 % of PTC overexpressed MUC1. Importantly, we observed firstly that CD176 was expressed in 63 % of PTC, but was faintly or not expressed in normal thyroid tissues and benign thyroid disease tissues, indicating that CD176 is also a tumour-associated antigen for PTCs. Moreover, expression of CD176 was strongly correlated with MUC1 by immunohistochemical staining in PTCs. Furthermore, we used the immunochemical method to confirm that MUC1 is a common and main carrier of CD176 in PTCs. Our data demonstrated that MUC1 and CD176 might be promising biomarkers for thyroid cancer.

• Authors: Xiang-xiang Zhan, Bing Zhao, Chang Diao, Yi Cao, Ruo-chuan Cheng
• Journal: Endocrine pathology (Endocr Pathol) Vol. 26 Issue 1 Pg. 21-6 (Mar 2015) ISSN: 1559-0097 [Electronic] United States
• PMID: 25614211 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Tumor-Associated, Carbohydrate
• Biomarkers, Tumor
• MUC1 protein, human
• Mucin-1
• Thomsen-Friedenreich antigen

Topics

• Adult
• Amino Acid Sequence
• Antigens, Tumor-Associated, Carbohydrate (biosynthesis)
• Biomarkers, Tumor
• Carcinoma (pathology)
• Carcinoma, Papillary (metabolism)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Immunohistochemistry
• Male
• Middle Aged
• Molecular Sequence Data
• Mucin-1 (biosynthesis)
• Thyroid Cancer, Papillary
• Thyroid Neoplasms (pathology)