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Relationships between interleukin-12B and interleukin-10 gene polymorphisms and hepatitis C in Chinese Han hemodialysis patients.

AbstractBACKGROUND AND AIMS:
Hepatitis C virus (HCV) commonly causes a chronic infection but portion of hemodialysis patients are able to resistant to HCV infection, even clear the virus naturally. Interleukin-10 (IL-10) and interleukin-12 (IL-12) are crucial regulators of the immune response to T-helper 1 (Th1) or T-helper 2 (Th2) categories and play a role in autoimmune and infectious diseases. This study was undertaken to investigate the possible association of genetic polymorphisms of 3' untranslated region (3'UTR) of the IL-12B (-1188) and IL-10 (-592 and -819) and hepatitis C in Chinese Han hemodialysis (HD) patients.
METHODS:
The genotyping of IL-12B 3'UTR and IL-10 -592 and -819 were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method.
RESULTS:
Compared with the IL-12B-AA genotype, CC and combined CC/AC genotypes were associated with a significant decreased risk of HCV infection in Chinese hemodialysis patients (p < 0.001). However, the IL-10-592 and -819 genotypes were not found significant difference both between the anti-HCV (+) and anti-HCV (-) patients (p > 0.05) and the persistent infection and viral clearance HD patients (p > 0.05).
CONCLUSIONS:
The present study indicated that the polymorphisms of IL-12B 3'UTR might contribute to the susceptibility of HCV infection in Chinese HD population.
AuthorsBei Zhu, Cuiyu Wang, Xiaoli Zhang, Juan He, Jianqing Wu, Rongbin Yu, Weihong Zhao
JournalRenal failure (Ren Fail) Vol. 37 Issue 3 Pg. 505-10 (Apr 2015) ISSN: 1525-6049 [Electronic] England
PMID25613737 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • IL10 protein, human
  • IL12B protein, human
  • Interleukin-12 Subunit p40
  • Interleukin-10
Topics
  • Adult
  • Aged
  • Asian People (genetics)
  • Female
  • Genetic Predisposition to Disease
  • Hepacivirus (isolation & purification, physiology)
  • Hepatitis C (complications, genetics, immunology)
  • Humans
  • Immunity, Cellular (genetics)
  • Interleukin-10 (genetics)
  • Interleukin-12 Subunit p40 (genetics)
  • Kidney Failure, Chronic (complications, therapy)
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Renal Dialysis (methods)

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