Abstract | BACKGROUND AND AIMS: METHODS: The genotyping of IL-12B 3'UTR and IL-10 -592 and -819 were performed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. RESULTS: Compared with the IL-12B-AA genotype, CC and combined CC/AC genotypes were associated with a significant decreased risk of HCV infection in Chinese hemodialysis patients (p < 0.001). However, the IL-10-592 and -819 genotypes were not found significant difference both between the anti-HCV (+) and anti-HCV (-) patients (p > 0.05) and the persistent infection and viral clearance HD patients (p > 0.05). CONCLUSIONS: The present study indicated that the polymorphisms of IL-12B 3'UTR might contribute to the susceptibility of HCV infection in Chinese HD population.
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Authors | Bei Zhu, Cuiyu Wang, Xiaoli Zhang, Juan He, Jianqing Wu, Rongbin Yu, Weihong Zhao |
Journal | Renal failure
(Ren Fail)
Vol. 37
Issue 3
Pg. 505-10
(Apr 2015)
ISSN: 1525-6049 [Electronic] England |
PMID | 25613737
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- IL10 protein, human
- IL12B protein, human
- Interleukin-12 Subunit p40
- Interleukin-10
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Topics |
- Adult
- Aged
- Asian People
(genetics)
- Female
- Genetic Predisposition to Disease
- Hepacivirus
(isolation & purification, physiology)
- Hepatitis C
(complications, genetics, immunology)
- Humans
- Immunity, Cellular
(genetics)
- Interleukin-10
(genetics)
- Interleukin-12 Subunit p40
(genetics)
- Kidney Failure, Chronic
(complications, therapy)
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Renal Dialysis
(methods)
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