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[High doses of aldosterone antagonist is a condition of sufficient blood pressure control in bilateral adrenal hyperplasia].

Abstract
Primary aldosteronism occurs in 1-10% of hypertensive patients and is classified in adenomas or bilateral adrenal hyperplasia. Computed tomography (CT) or magnetic resonance imaging can be used to discriminate these subtypes and in guiding treatment selection. This case report describes a 65-year-old man with hypertension and hypokalaemia during 25 years. Bilateral adrenal hyperplasia was diagnosed based on a CT, and an oral sodium-loading test with measurement of renin and aldosterone confirmed the diagnosis. Blood pressure and potassium in plasma was normalized during treatment with the mineralocorticoid receptor antagonist eplerenon.
AuthorsSafa Therwani, Erling Bjerregaard Pedersen
JournalUgeskrift for laeger (Ugeskr Laeger) Vol. 177 Issue 2A Pg. 44-5 (Jan 26 2015) ISSN: 1603-6824 [Electronic] Denmark
Vernacular TitleHøj dosis af aldosteronantagonist er nødvendig for god blodtrykskontrol ved bilateral adrenal hyperplasi.
PMID25612961 (Publication Type: Case Reports)
Chemical References
  • Mineralocorticoid Receptor Antagonists
  • Spironolactone
  • Eplerenone
Topics
  • Adrenal Glands (diagnostic imaging, pathology)
  • Aged
  • Eplerenone
  • Humans
  • Hyperplasia (drug therapy)
  • Hypertension (diagnosis, drug therapy)
  • Male
  • Mineralocorticoid Receptor Antagonists (administration & dosage, therapeutic use)
  • Spironolactone (administration & dosage, analogs & derivatives, therapeutic use)

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