HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Nadolol prevents the exercise-induced rise in lymphocyte beta-receptor number in borderline hypertension.

Abstract
Thirteen borderline hypertensives were investigated at rest and during dynamic exercise, before and after therapy with nadolol (40-80 mg/day for 7-28 days), in order to evaluate regulation of the number of lymphocyte beta-receptors. Systolic blood pressure and the heart rate were measured before and after 15 min of bicycle exercise, both with and without nadolol therapy; blood samples were withdrawn for adrenaline, noradrenaline and lymphocyte beta-receptor determinations. Nadolol induced a significant decrease in systolic blood pressure and the heart rate at rest, while plasma catecholamines and lymphocyte beta-receptors did not change significantly. Of the physiological responses to dynamic exercise (increases in systolic blood pressure, heart rate, plasma noradrenaline levels and adrenaline and lymphocyte beta-receptors), only the rise in beta-receptors was entirely prevented, and the increase in the heart rate was significantly attenuated by nadolol. It is suggested that the lack of a rise in the number of beta-receptors during exercise may contribute to the blunted exercise-induced tachycardia in patients taking nadolol.
AuthorsL Terzoli, R Bragato, G B Bolla, G Leonetti, A Zanchetti
JournalJournal of hypertension. Supplement : official journal of the International Society of Hypertension (J Hypertens Suppl) Vol. 7 Issue 6 Pg. S46-7 (Dec 1989) ISSN: 0952-1178 [Print] England
PMID2561149 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Receptors, Adrenergic, beta
  • Nadolol
Topics
  • Adult
  • Drug Evaluation
  • Humans
  • Hypertension (blood, drug therapy)
  • Lymphocytes (analysis, drug effects)
  • Middle Aged
  • Nadolol (therapeutic use)
  • Physical Exertion (drug effects, physiology)
  • Radioligand Assay
  • Receptors, Adrenergic, beta (analysis, drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: