Abstract |
Thirteen borderline hypertensives were investigated at rest and during dynamic exercise, before and after therapy with nadolol (40-80 mg/day for 7-28 days), in order to evaluate regulation of the number of lymphocyte beta-receptors. Systolic blood pressure and the heart rate were measured before and after 15 min of bicycle exercise, both with and without nadolol therapy; blood samples were withdrawn for adrenaline, noradrenaline and lymphocyte beta-receptor determinations. Nadolol induced a significant decrease in systolic blood pressure and the heart rate at rest, while plasma catecholamines and lymphocyte beta-receptors did not change significantly. Of the physiological responses to dynamic exercise (increases in systolic blood pressure, heart rate, plasma noradrenaline levels and adrenaline and lymphocyte beta-receptors), only the rise in beta-receptors was entirely prevented, and the increase in the heart rate was significantly attenuated by nadolol. It is suggested that the lack of a rise in the number of beta-receptors during exercise may contribute to the blunted exercise-induced tachycardia in patients taking nadolol.
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Authors | L Terzoli, R Bragato, G B Bolla, G Leonetti, A Zanchetti |
Journal | Journal of hypertension. Supplement : official journal of the International Society of Hypertension
(J Hypertens Suppl)
Vol. 7
Issue 6
Pg. S46-7
(Dec 1989)
ISSN: 0952-1178 [Print] England |
PMID | 2561149
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Receptors, Adrenergic, beta
- Nadolol
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Topics |
- Adult
- Drug Evaluation
- Humans
- Hypertension
(blood, drug therapy)
- Lymphocytes
(analysis, drug effects)
- Middle Aged
- Nadolol
(therapeutic use)
- Physical Exertion
(drug effects, physiology)
- Radioligand Assay
- Receptors, Adrenergic, beta
(analysis, drug effects)
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