Abstract | BACKGROUND: AIM: We evaluated whether URB937 alters nociceptive responses in the animal model of migraine based on NTG administration in male rats, using the tail flick test and the plantar and orofacial formalin tests, under baseline conditions and after NTG administration. Furthermore, we investigated whether URB937 affects NTG-induced c-Fos expression in the brain. RESULTS: During the tail flick test, URB937 showed an antinociceptive effect in baseline conditions and it blocked NTG-induced hyperalgesia. URB937 also proved effective in counteracting NTG-induced hyperalgesia during both the plantar and orofacial formalin tests. Mapping of brain nuclei activated by NTG indicates that URB937 significantly reduces c-Fos expression in the nucleus trigeminalis caudalis and the locus coeruleus. CONCLUSIONS: The data suggest that URB937 is capable of changing, probably via indirect mechanisms, the functional status of central structures that are important for pain transmission in an animal model of migraine.
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Authors | R Greco, T Bandiera, A S Mangione, C Demartini, F Siani, G Nappi, G Sandrini, A Guijarro, A Armirotti, D Piomelli, C Tassorelli |
Journal | Cephalalgia : an international journal of headache
(Cephalalgia)
Vol. 35
Issue 12
Pg. 1065-76
(Oct 2015)
ISSN: 1468-2982 [Electronic] England |
PMID | 25608877
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © International Headache Society 2015. |
Chemical References |
- Analgesics
- Cannabinoids
- URB937
- Amidohydrolases
- fatty-acid amide hydrolase
- Nitroglycerin
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Topics |
- Amidohydrolases
(antagonists & inhibitors)
- Analgesics
(administration & dosage)
- Animals
- Cannabinoids
(administration & dosage)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Hyperalgesia
(chemically induced, physiopathology, prevention & control)
- Male
- Nitroglycerin
- Pain Perception
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Treatment Outcome
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