A single-blinded randomized controlled study to assess the efficacy of twice daily application of sinecatechins 15% ointment when used sequentially with cryotherapy in the treatment of external genital warts.

Abstract

OBJECTIVE:

To evaluate the efficacy of sequential therapy of cryotherapy and sinecatechins 15% ointment BID versus cryotherapy alone in treatment of external genital warts (EGW).

METHODS:

Forty-two subjects with at least two EGW lesions underwent cryotherapy to all lesions. One week following cryotherapy, subjects were randomized 1:1 to receive either no additional treatment or treatment with sinecatechins 15% ointment BID up to 16 weeks or until complete clearance. The total number of visible baseline and new EGW were recorded at each visit. Subjects were followed for a total of 65 weeks post-treatment.

RESULTS:

There was a significant reduction in mean number of lesions from baseline after 16 weeks of treatment in the cryotherapy-sinecatechins ointment group compared to cryotherapy alone (-5.0 lesions vs -2.1 lesions respectively, P=0.07).

CONCLUSION:

Cryotherapy plus sinecatechins 15% ointment BID resulted in a significant improvement in the reduction of EGW compared to cryotherapy alone. Clinicaltrials.gov registration identifier: NCT02147353.

• Authors: Shelbi C Jim On, Rita V Linkner, Madelaine Haddican, Alex Yaroshinsky, Matthew Gagliotti, Giselle Singer, Gary Goldenberg
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 13 Issue 11 Pg. 1400-5 (Nov 2014) ISSN: 1545-9616 [Print] United States
• PMID: 25607709 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Catechin

Topics

• Administration, Topical
• Adult
• Catechin (administration & dosage, analogs & derivatives, therapeutic use)
• Combined Modality Therapy
• Condylomata Acuminata (therapy)
• Cryotherapy (methods)
• Follow-Up Studies
• Humans
• Single-Blind Method
• Treatment Outcome