In vivo effect of flucloxacillin in experimental endocarditis caused by mecC-positive staphylococcus aureus showing temperature-dependent susceptibility in vitro.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) carrying the mecC gene (mecC-MRSA) exhibited at 37°C MICs of oxacillin close to those of methicillin-susceptible S. aureus (MSSA). We investigated whether at this temperature, mecC-MRSA strains respond to flucloxacillin treatment like MSSA strains, using a rat model of endocarditis. Flucloxacillin (human-like kinetics of 2 g intravenously every 6 h) cured 80 to 100% of aortic vegetations infected with five different mecC-MRSA strains. These results suggest that mecC-MRSA infections may successfully respond to treatment with β-lactams.

• Authors: Stefano Mancini, Frédéric Laurent, Tiago R Veloso, Marlyse Giddey, Jacques Vouillamoz, François Vandenesch, Philippe Moreillon, José M Entenza
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 59 Issue 4 Pg. 2435-8 (Apr 2015) ISSN: 1098-6596 [Electronic] United States
• PMID: 25605361 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Chemical References

• Anti-Bacterial Agents
• Floxacillin
• Cefoxitin
• Oxacillin

Topics

• Animals
• Anti-Bacterial Agents (administration & dosage, therapeutic use)
• Aorta (microbiology)
• Cefoxitin (pharmacology)
• Chromatography, Micellar Electrokinetic Capillary
• Endocarditis, Bacterial (drug therapy, microbiology)
• Floxacillin (administration & dosage, therapeutic use)
• Infusion Pumps
• Methicillin-Resistant Staphylococcus aureus (genetics)
• Microbial Sensitivity Tests
• Oxacillin (pharmacology)
• Rats
• Staphylococcal Infections (drug therapy, microbiology)
• Temperature