Abstract | BACKGROUND: METHODS: A total of 68 consecutive patients diagnosed with first-ever lacunar infarction (<20 mm) within 24 hours of symptom onset were included in this study. Clinical, laboratory, and imaging data were obtained. Plasma levels of VEGF, SDF-1α, MIF, and HMGB1 were assessed using Enzyme-Linked Immunosorbent Assay kits. RESULTS: SBIs were noted in 31 of the 68 patients. Although the initial National Institutes of Health Stroke Scale scores were not related with the presence of SBIs (P = .313), patients with SBIs had better outcomes at 3 months (P = .029). Additionally, plasma VEGF levels were higher (P = .035) and SDF-1α levels were lower (P < .001) in patients with SBIs. Logistic regression analysis indicated that VEGF and SDF-1α were independently associated with the presence of SBIs. CONCLUSIONS: SBIs are associated with favorable outcomes in patients with first-ever acute lacunar infarction and higher levels of VEGF, and lower levels of SDF-1α in these patients may contribute to their more favorable prognosis.
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Authors | Hyuk Sung Kwon, Young Seo Kim, Hyun-Hee Park, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Sung Hyuk Heo, Dae-Il Chang, Seong-Ho Koh |
Journal | Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
(J Stroke Cerebrovasc Dis)
Vol. 24
Issue 3
Pg. 704-10
(Mar 2015)
ISSN: 1532-8511 [Electronic] United States |
PMID | 25601176
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- CXCL12 protein, human
- Chemokine CXCL12
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biomarkers
(blood)
- Chemokine CXCL12
(blood)
- Chi-Square Distribution
- Disability Evaluation
- Down-Regulation
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Logistic Models
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Odds Ratio
- Predictive Value of Tests
- Prognosis
- Risk Factors
- Stroke, Lacunar
(blood, diagnosis, etiology, therapy)
- Time Factors
- Up-Regulation
- Vascular Endothelial Growth Factor A
(blood)
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