Wheat allergy in children evaluated with challenge and IgE antibodies to wheat components.

Abstract

INTRODUCTION:

Wheat sensitization is common but IgE antibodies (IgE-abs) to wheat are not predictive of clinical symptoms in children with suspected wheat allergy. Wheat allergen components other than ω-5 gliadin have not been well studied. Our aim was to characterize the clinical profile and investigate the value of adding measurements of IgE-abs to wheat components in a group of children with a doctor's diagnosed wheat allergy.

METHOD:

Sixty-three children with a doctor's diagnosis of wheat allergy confirmed sensitization to wheat and, on a wheat elimination diet, went through oral wheat challenges or had a convincing recent history of wheat allergy. IgE-ab to ω-5 gliadin, low molecular weight glutenin (LMW-glutenin), high molecular weight glutenin (HMW-glutenin) and a native gliadin preparation containing α-, β-, γ-, and ω-gliadin (gliadin) were analyzed.

RESULTS:

Twenty-six children were positive in challenge, while six children were regarded as wheat allergic due to recent anaphylactic reactions. The IgE-ab levels to all four wheat components were significantly higher in the group with wheat allergy compared to the group with no wheat allergy (p < 0.0001). Also, the severity of symptoms at challenge correlated with the IgE-ab levels to all four components (p < 0.05). IgE-ab levels to ω-5 gliadin correlated best with challenge outcome, and by additional analysis of gliadin, HMW- and LMW-glutenin IgE-abs all challenge positive children could be identified.

CONCLUSION:

Many children diagnosed as wheat allergic have outgrown their allergy and are unnecessarily on a wheat-free diet. The levels of IgE-ab to wheat gluten-derived components correlated well with wheat challenge outcome and severity.

• Authors: Nora Nilsson, Sigrid Sjölander, Alexandra Baar, Malin Berthold, Sandra Pahr, Susanne Vrtala, Rudolf Valenta, Eishin Morita, Gunilla Hedlin, Magnus P Borres, Caroline Nilsson
• Journal: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (Pediatr Allergy Immunol) Vol. 26 Issue 2 Pg. 119-25 (Mar 2015) ISSN: 1399-3038 [Electronic] England
• PMID: 25601168 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Allergens
• Immunoglobulin E

Topics

• Adolescent
• Allergens (immunology)
• Child
• Child, Preschool
• Female
• Humans
• Immunoglobulin E (blood)
• Immunologic Tests (methods)
• Infant
• Male
• Wheat Hypersensitivity (diagnosis, immunology)