Abstract | INTRODUCTION: Wheat sensitization is common but IgE antibodies ( IgE-abs) to wheat are not predictive of clinical symptoms in children with suspected wheat allergy. Wheat allergen components other than ω-5 gliadin have not been well studied. Our aim was to characterize the clinical profile and investigate the value of adding measurements of IgE-abs to wheat components in a group of children with a doctor's diagnosed wheat allergy. METHOD: RESULTS: Twenty-six children were positive in challenge, while six children were regarded as wheat allergic due to recent anaphylactic reactions. The IgE-ab levels to all four wheat components were significantly higher in the group with wheat allergy compared to the group with no wheat allergy (p < 0.0001). Also, the severity of symptoms at challenge correlated with the IgE-ab levels to all four components (p < 0.05). IgE-ab levels to ω-5 gliadin correlated best with challenge outcome, and by additional analysis of gliadin, HMW- and LMW- glutenin IgE-abs all challenge positive children could be identified. CONCLUSION: Many children diagnosed as wheat allergic have outgrown their allergy and are unnecessarily on a wheat-free diet. The levels of IgE-ab to wheat gluten-derived components correlated well with wheat challenge outcome and severity.
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Authors | Nora Nilsson, Sigrid Sjölander, Alexandra Baar, Malin Berthold, Sandra Pahr, Susanne Vrtala, Rudolf Valenta, Eishin Morita, Gunilla Hedlin, Magnus P Borres, Caroline Nilsson |
Journal | Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
(Pediatr Allergy Immunol)
Vol. 26
Issue 2
Pg. 119-25
(Mar 2015)
ISSN: 1399-3038 [Electronic] England |
PMID | 25601168
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Chemical References |
- Allergens
- Immunoglobulin E
|
Topics |
- Adolescent
- Allergens
(immunology)
- Child
- Child, Preschool
- Female
- Humans
- Immunoglobulin E
(blood)
- Immunologic Tests
(methods)
- Infant
- Male
- Wheat Hypersensitivity
(diagnosis, immunology)
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