Abstract | PURPOSE: The capillary leak syndrome (CLS) is a rare condition characterized by the onset of hypotension, edema, hemoconcentration and hypoalbuminemia. CLS can be idiopathic (Clarkson's disease) or secondary to various conditions and treatments. Here, we review the clinical and biological features, pathophysiology, causes and treatment of this rare condition. METHODS: We performed a systematic review of the literature (Medline database through February 2014) to identify all articles about CLS. The relevant references were selected by two independent authors. RESULTS: CONCLUSION: Clarification of the pathophysiological mechanisms of CLS is essential to improve the prognosis of this rare disease with more targeted treatments.
|
Authors | L Duron, F Delestre, Z Amoura, L Arnaud |
Journal | La Revue de medecine interne
(Rev Med Interne)
Vol. 36
Issue 6
Pg. 386-94
(Jun 2015)
ISSN: 1768-3122 [Electronic] France |
Vernacular Title | Syndrome de fuite capillaire idiopathique et formes secondaires : une revue systématique de la littérature. |
PMID | 25600329
(Publication Type: Journal Article, Review, Systematic Review)
|
Copyright | Copyright © 2014 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved. |
Topics |
- Capillary Leak Syndrome
(diagnosis, physiopathology, therapy)
- Diagnosis, Differential
- Female
- Humans
- Male
- Prognosis
|