Metabolic factors in diffuse idiopathic skeletal hyperostosis - a review of clinical data.

Abstract

OBJECTIVES:

We aimed to review the literature linking metabolic factors to Diffuse Idiopathic Skeletal Hyperostosis (DISH), in order to assess associations between growth factors and DISH.

METHOD:

We identified studies in our personal database and PubMed using the following keywords in various combinations: "diffuse idiopathic skeletal hyperostosis", "ankylosing hyperostosis", "Forestier's disease", "diabetes", "insulin", "obesity", "metabolic", "growth factors", "adipokines", "glucose tolerance" and "chondrocytes".

RESULTS:

We were not able to do a systematic review due to variability in methodology of studies. We found positive associations between obesity (especially abdominal obesity), Type 2 diabetes mellitus, glucose intolerance, hyperinsulinemia and DISH.

CONCLUSION:

Current research indicates that certain metabolic factors associate with DISH. More precise studies deriving from these findings on these and other newly identified bone-growth factors are needed.

• Authors: Sruti Pillai, Geoffrey Littlejohn
• Journal: The open rheumatology journal (Open Rheumatol J) Vol. 8 Pg. 116-28 ( 2014) ISSN: 1874-3129 [Print] United Arab Emirates
• PMID: 25598855 (Publication Type: Journal Article)