Abstract | BACKGROUND: Chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) is a principally type 2 T helper cell (Th2)-mediated inflammatory disease. Systemic corticosteroids currently represent the most effective treatment for CRSwNP, but their long-term use is constrained due to their detrimental side effects. Long-term use of topical steroids is safe, but their efficacy is often limited. Topical cyclosporine has proven to be safe and effective for Th2-mediated diseases such as allergic conjunctivitis. OBJECTIVE: It was hypothesized that topical cyclosporine would be an effective novel drug for the treatment of CRSwNP; its therapeutic efficacy was assessed using a previously established mouse model. METHODS: RESULTS: The number of polyp-like lesions was reduced significantly only by systemic TAC, but the degree of eosinophilic infiltration was decreased significantly by topical cyclosporine, the potency of which was similar to that of topical or systemic TAC. Except for IFN-γ, the majority of measured cytokines were reduced significantly by topical cyclosporine, although their effects on IL-2 and IL-13 were less potent than those of systemic TAC. CONCLUSION:
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Authors | Dong-Yeop Chang, Yeon-Hee Joo, Seong-Jae Kim, Jin Hyun Kim, Myeong Hee Jung, Dae Woo Kim, Sea-Yuong Jeon, Sang-Wook Kim |
Journal | American journal of rhinology & allergy
(Am J Rhinol Allergy)
2015 Jan-Feb
Vol. 29
Issue 1
Pg. e29-32
ISSN: 1945-8932 [Electronic] United States |
PMID | 25590314
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Intranasal
- Animals
- Cyclosporine
(administration & dosage)
- Cytokines
(analysis)
- Disease Models, Animal
- Eosinophilia
(drug therapy)
- Mice
- Mice, Inbred BALB C
- Nasal Polyps
(drug therapy, immunology, pathology)
- Rhinitis
(drug therapy, immunology, pathology)
- Sinusitis
(drug therapy, immunology, pathology)
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