Abstract | BACKGROUND: MATERIALS AND METHODS: We studied 2 series of patients with TNBC, one from Kumamoto University Hospital composed of 16 matched cases of primary and locally or distal recurrences and the other from Tohoku University Hospital examining 46 lymph node metastasis from 23 patients. In addition to studying concordance in AR expression, we also examined the interactions between AR and Ki-67 labeling index and AR and site of distal metastasis. RESULTS: In both series, AR status was concordant between primary and recurrent/metastatic disease, but coordinated expression of AR and androgenic enzymes was lost during the process. The inverse association between AR and Ki-67, previously reported in invasive ductal carcinoma (IDC), was markedly potentiated in both lymph node and recurrent cancers. In addition, AR expression appeared to have little effect on visceral metastasis but was associated directly with bone metastasis and inversely with brain metastasis. CONCLUSIONS: The results of our present study demonstrated that AR remained in the majority of metastatic samples from AR-positive primary TNBCs and that AR manipulation could be exploited in the metastatic settings of TNBC.
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Authors | Keely May McNamara, Tomomi Yoda, Yasuhiro Miki, Yasuhiro Nakamura, Takashi Suzuki, Noriko Nemoto, Minoru Miyashita, Reiki Nishimura, Nobuyuki Arima, Kentaro Tamaki, Takanori Ishida, Noriaki Ohuchi, Hironobu Sasano |
Journal | The International journal of biological markers
(Int J Biol Markers)
Vol. 30
Issue 2
Pg. e184-9
(May 26 2015)
ISSN: 1724-6008 [Electronic] United States |
PMID | 25588857
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Female
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Receptors, Androgen
(metabolism)
- Triple Negative Breast Neoplasms
(blood, pathology)
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