Prefeeding of aldose reductase inhibitor and galactose cataractogenesis.

Our recent investigations have shown that the Eisai compound, E-0722, (2R-4S-6-fluoro-1-2-methylspirochroman 4,4'-imidazolidine 2,5'-dione) is a more potent aldose reductase inhibitor than Sorbinil (D-6-fluorospirochroman 4,4'-imidazolidine 2,5'-dione). In the previous studies these aldose reductase inhibitors were added to the 50% galactose diet fed to rats to determine their effect on galactose-induced alterations in the lens and the development of cataract. In this report we present our results on the effect of prefeeding the aldose reductase inhibitor, E-0722, on the alterations in rat lens following subsequent feeding of galactose. For this study, young Sprague Dawley rats were prefed either rat chow or rat chow plus 50% galactose containing 1mg/day/Kg body weight of E-0722 for 1 or 2 weeks. After this dietary regimen, the animals were transferred to diets containing 50% galactose for different periods. For controls, rats were fed either rat chow or 50% galactose without the prefeeding of E-0722. Our results obtained through gross observation of the lenses, light microscopic studies of lens sections and assay of Na+-K+-ATPase (NPPase) activity show that the prefeeding of E-0722 prior to galactose feeding delays galactose-induced alterations and the development of mature cataract.
AuthorsN J Unakar, J Y Tsui, M J Johnson
JournalCurrent eye research (Curr Eye Res) Vol. 8 Issue 10 Pg. 997-1010 (Oct 1989) ISSN: 0271-3683 [Print] ENGLAND
PMID2558845 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Imidazoles
  • Imidazolidines
  • M 79175
  • Sugar Alcohol Dehydrogenases
  • Aldehyde Reductase
  • Sodium-Potassium-Exchanging ATPase
  • Galactose
  • Aldehyde Reductase (antagonists & inhibitors)
  • Animals
  • Cataract (enzymology, etiology, pathology)
  • Diet
  • Galactose (administration & dosage, antagonists & inhibitors)
  • Imidazoles (pharmacology)
  • Imidazolidines
  • Lens, Crystalline (pathology)
  • Rats
  • Rats, Inbred Strains
  • Sodium-Potassium-Exchanging ATPase (metabolism)
  • Sugar Alcohol Dehydrogenases (antagonists & inhibitors)

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