Maraviroc Failed to Control Progressive Multifocal Leukoencephalopathy-Associated IRIS in a Patient with Advanced HIV Infection.

Abstract

Due to the lack of therapeutic options for patients with progressive multifocal leukoencephalopathy-associated immune reconstitution inflammatory syndrome (PML-associated IRIS), maraviroc has generated expectations among the medical community. However, we report a patient with advanced HIV infection, who developed PML-associated IRIS and had a fatal outcome despite the addition of maraviroc to suppressive ART. Future studies are required to define the therapeutic role of maraviroc in PML-associated IRIS and differentiate individuals who may benefit from maraviroc from those who may develop neurological deterioration.

• Authors: Mónica Rodríguez, Fernando Antonio Silva-Sánchez, César Luna-Rivero, Ricardo Vega-Barrientos, Claudia Alvarado-de la Barrera, Gustavo Reyes-Terán
• Journal: Case reports in medicine (Case Rep Med) Vol. 2014 Pg. 381480 ( 2014) ISSN: 1687-9627 [Print] United States
• PMID: 25587282 (Publication Type: Journal Article)