Asthma and the hygiene hypothesis. Does cleanliness matter?

Abstract

RATIONALE:

The early hygiene hypothesis explained the development of allergies by a lack of infections; nowadays, the aspect of excessive cleanliness in affluent populations seems to have replaced this concept. Yet, no investigation has shown that home or personal cleanliness relate to allergic diseases.

OBJECTIVES:

To relate personal and home cleanliness to risk of asthma and allergies.

METHODS:

Comprehensive questionnaire information on home or personal cleanliness and allergic health conditions at school age was collected in 399 participants of the urban Perinatale Asthma Umwelt Langzeit Allergie Studie (PAULA) birth cohort. Bacterial markers were assessed in floor and mattress dust and were related to cleanliness and allergic diseases.

MEASUREMENTS AND MAIN RESULTS:

Personal cleanliness was inversely related to bacterial compounds on floors and mattresses, whereas home cleanliness effectively reduced dust amount but not microbial markers. Exposure to muramic acid related to a lower prevalence of school-age asthma (adjusted odds ratio, 0.59 [95% confidence interval, 0.39; 0.90]). Mattress endotoxin in the first year of life was inversely associated with atopic sensitization (0.73 [0.56-0.96]) and asthma at school age (0.72 [0.55-0.95]). Despite the associations of dust parameters both with cleanliness and allergic health conditions, the development of allergies was not related to home and personal cleanliness.

CONCLUSIONS:

Bacterial exposure in house dust determined childhood asthma and allergies. Personal cleanliness, such as washing hands, and home cleanliness were objectively reflected by dust parameters in homes. However, neither personal nor home cleanliness was associated with a risk for asthma and allergies. Other microbial components in house dust not affected by personal hygiene are likely to play a role.

• Authors: Juliane Weber, Sabina Illi, Dennis Nowak, Rudolf Schierl, Otto Holst, Erika von Mutius, Markus J Ege
• Journal: American journal of respiratory and critical care medicine (Am J Respir Crit Care Med) Vol. 191 Issue 5 Pg. 522-9 (Mar 01 2015) ISSN: 1535-4970 [Electronic] United States
• PMID: 25584716 (Publication Type: Journal Article)

Chemical References

• Dust
• Endotoxins
• Muramic Acids

Topics

• Asthma (immunology)
• Dust (analysis, immunology)
• Endotoxins (analysis)
• Humans
• Hygiene
• Hygiene Hypothesis
• Hypersensitivity (immunology)
• Life Style
• Muramic Acids (analysis)
• Risk Assessment