Effect of neurokinin A on human temporal muscle blood flow.

Abstract

The effect of neurokinin A on human temporal muscle blood flow was compared to saline when injected into the muscle in six normal subjects. The 133-Xenon washout technique was used and the test solutions administered in a double-blind, cross-over manner. Neurokinin A (0.02 ml, 10(-5)M) caused a blood flow increase of 193%, while saline caused an increase of 23%. The difference between neurokinin A and saline was significant (p less than 0.05). It is suggested that a possible pathophysiological role of neurokinin A in migraine must involve modulation of vascular response as well as of primary nociception.

• Authors: C Tuxen, K Jensen, M Kjeldsen, L Edvinsson, I Jansen, J Olesen
• Journal: Peptides (Peptides) 1989 Sep-Oct Vol. 10 Issue 5 Pg. 921-4 ISSN: 0196-9781 [Print] United States
• PMID: 2558365 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)

Chemical References

• Neurokinin A

Topics

• Adult
• Blood Pressure (drug effects)
• Double-Blind Method
• Female
• Heart Rate (drug effects)
• Humans
• Male
• Mastication (physiology)
• Masticatory Muscles (drug effects)
• Neurokinin A (pharmacology)
• Regional Blood Flow (drug effects)
• Temporal Muscle (blood supply, drug effects)