Abstract |
The aim of the present study is to verify the trapping effect of combretastatin A-4-phosphate (CA4P) on small molecular drugs in rodent tumors. Mice with H22 hepatocarcinoma were randomized into groups A and B. Magnetic resonance imaging (MRI) of T1WI, T2WI, and DWI was performed as baseline. Mice in group A were injected with Gd-DTPA and PBS. Mice in group B were injected with Gd-DTPA and CA4P. All mice undergo CE-T1WI at 0 h, 3 h, 6 h, 12 h, and 24 h. Enhancing efficacy of the two groups on CE-T1WI was compared with the signal-to-noise ratio (SNR) calculated. Concentrations of gadolinium measured by ICP-AES in the tumor were compared between groups. On the early CE-T1WI, tumors were equally enhanced in both groups. On the delayed CE-T1WI, the enhancing effect of group A was weaker than that of group B. The SNR and the concentration of gadolinium within the tumor of group A were lower than that of group B at 6 h, 12 h, and 24 h after administration. This study indicates that CA4P could improve the retention of Gd-DTPA in the tumor and MRI allowed dynamically monitoring trapping effects of CA4P on local retention of Gd-DTPA as a small molecular drug.
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Authors | Meng Gao, Nan Yao, Dejian Huang, Cuihua Jiang, Yuanbo Feng, Yue Li, Bin Lou, Fei Peng, Ziping Sun, Yicheng Ni, Jian Zhang |
Journal | Journal of drug targeting
(J Drug Target)
Vol. 23
Issue 5
Pg. 436-43
(Jun 2015)
ISSN: 1029-2330 [Electronic] England |
PMID | 25582132
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Contrast Media
- Stilbenes
- fosbretabulin
- Gadolinium DTPA
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Topics |
- Animals
- Antineoplastic Agents, Phytogenic
(pharmacology)
- Carcinoma, Hepatocellular
(drug therapy, pathology)
- Contrast Media
(administration & dosage, pharmacokinetics)
- Disease Models, Animal
- Gadolinium DTPA
(administration & dosage, pharmacokinetics)
- Liver Neoplasms
(drug therapy, pathology)
- Magnetic Resonance Imaging
(methods)
- Male
- Mice
- Spectrophotometry, Atomic
(methods)
- Stilbenes
(pharmacology)
- Time Factors
- Tissue Distribution
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