Abstract | OBJECTIVE: STUDY DESIGN: RESULTS: The study cohort comprised 1335 women; 870 (65.2%) women received methylergonovine and 465 (34.8%) women received carboprost. After accounting for potential confounders, the risk of hemorrhage-related morbidity was higher in the carboprost group than the methylergonovine group (relative risk, 1.7; 95% confidence interval, 1.2-2.6). CONCLUSION: In this propensity score-matched analysis, methylergonovine was associated with reduced risk of hemorrhage-related morbidity during cesarean delivery compared to carboprost. Based on these results, methylergonovine may be a more effective second-line uterotonic.
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Authors | Alexander J Butwick, Brendan Carvalho, Yair J Blumenfeld, Yasser Y El-Sayed, Lorene M Nelson, Brian T Bateman |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 212
Issue 5
Pg. 642.e1-7
(May 2015)
ISSN: 1097-6868 [Electronic] United States |
PMID | 25582104
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Oxytocics
- Carboprost
- Methylergonovine
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Topics |
- Adult
- Carboprost
(therapeutic use)
- Cesarean Section
- Cohort Studies
- Erythrocyte Transfusion
(statistics & numerical data)
- Female
- Humans
- Hysterectomy
- Ligation
- Methylergonovine
(therapeutic use)
- Oxytocics
(therapeutic use)
- Postpartum Hemorrhage
(therapy)
- Pregnancy
- Propensity Score
- Risk Factors
- Uterine Artery
(surgery)
- Uterine Inertia
(therapy)
- Young Adult
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