A Prospective Randomized Trial Comparing Pneumatic Lithotripsy and Holmium Laser for Management of Middle and Distal Ureteral Calculi.

Abstract

PURPOSE:

The aim of this study was to compare the efficacy and safety between pneumatic and holmium:yttrium-aluminum-garnet (Ho:YAG) laser in the treatment of patients with ureteral stones located in the middle and distal ureter.

PATIENTS AND METHODS:

We conducted a prospective study in recruiting 982 eligible patients from 2009 to 2012. Patients were randomly divided into two groups-the pneumatic lithotripsy (PL) group or the Ho:YAG laser lithotripsy (LL) group. Patient demographics, stone characteristics, intraoperative parameters, and postoperative complications were evaluated and analyzed.

RESULTS:

The baseline demographics of patients and stone characteristics were similar in the two groups. The LL group showed significant benefits compared with the PL group in terms of mean operative time (28±9.2 vs 41±12.4 min, P=0.001) and early stone-free rate (80.8% vs 91.3%, P=0.04), but there was no statistically significant difference at the third month (92.6% vs 95.5%, P=0.15). In the LL group, 24 postoperative cases of stricture were seen, whereas only 5 cases occurred in the PL group (P=0.02). The other complications, such as perforation, bleeding, and mucosal injury, were comparable in the two groups. The average postoperative stay was also similar (1.7±2.4 days for PL and 1.5±3.1 days for LL (P=0.62).

CONCLUSION:

Both PL and LL are effective in the management of middle and distal impacted stones. Ho:YAG laser has advantages in better efficacy of stone fragmentation and a higher early stone-free rate but seems to have to face the increased risks of postoperative stricture.

• Authors: Linjin Li, Yue Pan, Zhiliang Weng, Wenshuo Bao, Zhixian Yu, Feng Wang
• Journal: Journal of endourology (J Endourol) Vol. 29 Issue 8 Pg. 883-7 (Aug 2015) ISSN: 1557-900X [Electronic] United States
• PMID: 25578351 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Holmium

Topics

• Adult
• Aged
• Constriction, Pathologic (surgery)
• Female
• Holmium (therapeutic use)
• Humans
• Lasers, Solid-State (therapeutic use)
• Lithotripsy, Laser (adverse effects, methods)
• Male
• Middle Aged
• Operative Time
• Postoperative Complications (etiology)
• Postoperative Period
• Prospective Studies
• Ureteral Calculi (surgery)