[Characteristics of the action of euphylline and the activity of forms of cAMP phosphodiesterase in lymphocytes of patients with bronchial asthma].

Abstract

Two forms of cAMP phosphodiesterase were isolated from lymphocytes by using centrifugation in sucrose density gradient. The activities of both forms do not differ in healthy persons and in patients with bronchial asthma during asphyxia-free period. During the attack the activity of the high molecular form of the enzyme increases. Euphylline exerts the inhibitory effect on the activity and consequently on the general activity of the enzyme.

• Authors: S I Ialkut, S A Kotova, O B Belova
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1989 Sep-Oct Vol. 52 Issue 5 Pg. 81-3 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Osobennosti deĭstviia éufillina i aktivnost' form fosfodiésterazy tsAMF v limfotsitakh bol'nykh bronkhial'noĭ astmoĭ.
• PMID: 2557234 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Aminophylline
• 3',5'-Cyclic-AMP Phosphodiesterases

Topics

• 3',5'-Cyclic-AMP Phosphodiesterases (antagonists & inhibitors, blood)
• Aminophylline (therapeutic use)
• Asthma (drug therapy, enzymology)
• Drug Evaluation
• Humans
• Lymphocytes (drug effects, enzymology)
• Molecular Weight