Patient-specific contour-fitting sheet electrodes for electrocorticographic brain machine interfaces.

Abstract

Non-invasive localization of certain brain functions may be mapped on a millimeter level. However, the inter-electrode spacing of common clinical brain surface electrodes still remains around 10 mm, and some electrodes fail to measure cortical activity due to unconformable plain electrode sheets. Here, we present details on development of implantable electrodes for attaining higher quality electrocorticographic signals for use in functional brain mapping and brain-machine interfaces. We produced personalized sheet electrodes after the creation of individualized molds using a 3D-printer. We created arrays to fit the surface curvature of the brain and inside the central sulcus, with inter-electrode distances of 2.5 mm. Rat experiments undertaken indicated no long term toxicity. We were also able to custom design, rapidly manufacture, safely implant and confirm the efficacy of personalized electrodes, including the capability to attain meaningful high gamma-band information in an amyotrophic lateral sclerosis patient. This sheet electrode may contribute to the higher performance of BMI's.

• Authors: Masayuki Hirata, Shayne Morris, Hisato Sugata, Kojiro Matsushita, Takufumi Yanagisawa, Haruhiko Kishima, Toshiki Yoshimine
• Journal: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference (Annu Int Conf IEEE Eng Med Biol Soc) Vol. 2014 Pg. 5204-7 ( 2014) ISSN: 2694-0604 [Electronic] United States
• PMID: 25571166 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Amyotrophic Lateral Sclerosis (physiopathology)
• Animals
• Brain (physiopathology)
• Brain Mapping
• Brain-Computer Interfaces
• Electrocorticography (methods)
• Electrodes, Implanted
• Humans
• Male
• Precision Medicine
• Rats