HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Comparison of hydroxyethyl starch 6% and crystalloids for preloading in elective caesarean section under spinal anesthesia.

AbstractBACKGROUND:
Although controversial, many studies have shown effectiveness of colloid loading as a substitute for crystalloids on reducing the incidence of hypotension in spinal anesthesia. This study was conducted to compare the effects of three intravenous fluid regimens on hemodynamic changes following spinal anesthesia in cesarean section. The regimens included 6% Hydroxyethylstarch 130/0.4 (HES) as a colloid and two crystalloids (lactated ringer's solution and sodium chloride 0.9%).
MATERIAL & METHOD:
In a double-blind clinical trial, 90 otherwise healthy parturients candidate of elective caesarean section were randomly allocated to receive lactated ringer's solution (1000 ml), sodium chloride 0.9% (1000 ml) or HES (7.5 mL/Kg) as preloading before spinal anesthesia. Hemodynamic parameters including blood pressure and heart rate, umbilical cord blood pH and the neonatal Apgar score were compared among the three groups.
RESULTS:
There was no difference in the basic hemodynamic measurements among the three groups. The incidence of hypotension and required dose of ephedrine was lower in HES group (p=0.008). There was no significant difference in umbilical cord blood PH or Apgar scores among intervention groups.
CONCLUSION:
Preloading with HES is more effective than crystalloids in prevention hypotension after spinal anesthesia without significant difference in Apgar score and umblical cord blood pH.
AuthorsMahzad Alimian, Masood Mohseni, Reza Safaeian, Seyed Hamid Reza Faiz, Mohammad Azad Majedi
JournalMedical archives (Sarajevo, Bosnia and Herzegovina) (Med Arch) Vol. 68 Issue 4 Pg. 279-81 (Aug 2014) ISSN: 0350-199X [Print] Bosnia and Herzegovina
PMID25568553 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Hydroxyethyl Starch Derivatives
  • Isotonic Solutions
Topics
  • Adult
  • Anesthesia, Spinal
  • Blood Pressure (drug effects)
  • Cesarean Section
  • Double-Blind Method
  • Female
  • Heart Rate (drug effects)
  • Humans
  • Hydroxyethyl Starch Derivatives (administration & dosage, therapeutic use)
  • Hypotension (prevention & control)
  • Isotonic Solutions (administration & dosage, therapeutic use)
  • Pregnancy

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: