[Significance of CD123 in histiocytic necrotizing lymphadenitis].

Abstract

OBJECTIVE:

To investigate the mode of presentation, cytologic features of the plasmacytoid dendritic cells (pDC), and the expression of CD123 and its significance in Kikuchi's disease.

METHODS:

CD123 expression was evaluated by EliVision immunohistochemical staining in formalin-fixed and paraffin-embedded tissues from 30 cases of Kikuchi's disease, 5 cases of T cell lymphoma, 10 cases of reactive lymphoid hyperplasia and 10 cases of chronic tonsillitis.

RESULTS:

Clusters of CD123 positive PDC were observed in Kikuchi's disease (28 of 30 cases, 93.3%) and the staining intensity was more prominent in the PDC at the periphery of the lesion and around the high endothelial venule-like vessels. CD123 showed three staining patterns: membranous (10 cases, 33.3%), cytoplasmic (10 cases, 33.3%), and membranous and cytoplasmic (8 cases, 26.7%). In the control group, CD123 showed cytoplasmic staining in reactive hyperplasia and chronic tonsillitis. Regarding the staining intensity, 12 of 28 cases (42.9%) were 3+ for CD123, 8 of 28 cases (28.6%) were 2+, and 8 of 28 cases (28.6%) were 1+. In contrast, PDC clusters with 1+ staining intensity were observed in 1 of 10 cases of reactive lymphoid hyperplasia; 2 of 10 chronic tonsillitis diseases; and much less in T cell lymphoma.

CONCLUSIONS:

Large cluster of PDC is detected in both proliferative and necrotizing types of Kikuchi's disease, making this a useful adjunctive diagnostic marker.

• Authors: Xuejing Wei, Xiaoge Zhou, Jianlan Xie, Xiaodan Zheng, Yuanyuan Zheng
• Journal: Zhonghua bing li xue za zhi = Chinese journal of pathology (Zhonghua Bing Li Xue Za Zhi) Vol. 43 Issue 10 Pg. 680-4 (Oct 2014) ISSN: 0529-5807 [Print] China
• PMID: 25567595 (Publication Type: Journal Article)

Topics

• Adult
• Aged
• Chronic Disease
• Dendritic Cells (metabolism, pathology)
• Female
• Histiocytic Necrotizing Lymphadenitis (metabolism, pathology)
• Humans
• Lymphoma, T-Cell (metabolism, pathology)
• Male
• Middle Aged
• Pseudolymphoma (metabolism, pathology)
• Staining and Labeling
• Tonsillitis (metabolism, pathology)