[Efficacy of intranasal antihistamine in the treatment of allergic rhinitis: a meta-analysis].

Abstract

OBJECTIVE:

To systematically evaluate the efficacy of intranasal antihistamine in the treatment of allergic rhinitis.

METHODS:

The randomized controlled trials (RCT) about intranasal antihistamines for the treatment of allergic rhinitis between January 1985 and January 2014 were searched in OVID, PubMed, EMBASE, CNKI, WanFang Data and Cochrane Library. Two reviewers independently screened the literatures, extracted the data, and evaluated the methodological quality, then meta-analysis was performed by using RevMan 5.1 software.

RESULTS:

A total of thirteen RCTs were included. The results of meta-analysis showed that the efficacy of intranasal antihistamine group was superior to the placebo group in total nasal symptom scores (TNSS), the difference was significant[WMD = -1.96, 95%CI (-2.06;-1.85), P < 0.01], and individual nasal symptom scores (blocked nose, rhinorrhea, and sneezing) [WMD = -0.18, 95%CI (-0.28;-0.08); WMD = -0.45, 95%CI (-0.52;-0.38); WMD = -0.41, 95%CI (-0.58;-0.24), all P < 0.01], with significant differences. There was no significant difference between the intranasal antihistamine group and the corticosteroid group in TNSS [WMD = -1.51, 95%CI (-3.51;0.49), P = 0.14], but the intranasal antihistamines group was superior to the corticosteroid group in individual nasal symptom scores (blocked nose, rhinorrhea, and sneezing) [WMD = -0.23, 95%CI (-0.40;-0.06); WMD = -0.35, 95%CI (-0.65;-0.05); WMD = -0.25, 95%CI (-0.42;-0.08), all P < 0.05], with significant differences. The intranasal antihistamine group was superior to the oral antihistamines group in TNSS [WMD = -0.88, 95%CI (-1.51;-0.25), P < 0.01].

CONCLUSION:

Intranasal antihistamine is effective in the control of nasal symptoms in AR patients.

• Authors: Shaoyan Feng, Chuntao Deng, Lei Li, Wei Liao, Yunping Fan, Geng Xu, Huabin Li
• Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery (Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi) Vol. 49 Issue 10 Pg. 832-8 (Oct 2014) ISSN: 1673-0860 [Print] China
• PMID: 25567439 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Adrenal Cortex Hormones
• Anti-Allergic Agents
• Histamine Antagonists
• Histamine H1 Antagonists

Topics

• Administration, Intranasal
• Adrenal Cortex Hormones
• Anti-Allergic Agents (administration & dosage, therapeutic use)
• Histamine Antagonists
• Histamine H1 Antagonists
• Humans
• Nasal Obstruction
• Rhinitis, Allergic (drug therapy)
• Rhinitis, Allergic, Seasonal
• Software