Abstract |
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Authors | Georg Jaeschke, Sabine Kolczewski, Will Spooren, Eric Vieira, Nadia Bitter-Stoll, Patrick Boissin, Edilio Borroni, Bernd Büttelmann, Simona Ceccarelli, Nicole Clemann, Beatrice David, Christoph Funk, Wolfgang Guba, Anthony Harrison, Thomas Hartung, Michael Honer, Jörg Huwyler, Martin Kuratli, Urs Niederhauser, Axel Pähler, Jens-Uwe Peters, Ann Petersen, Eric Prinssen, Antonio Ricci, Daniel Rueher, Marianne Rueher, Manfred Schneider, Paul Spurr, Theodor Stoll, Daniel Tännler, Jürgen Wichmann, Richard H Porter, Joseph G Wettstein, Lothar Lindemann |
Journal | Journal of medicinal chemistry
(J Med Chem)
Vol. 58
Issue 3
Pg. 1358-71
(Feb 12 2015)
ISSN: 1520-4804 [Electronic] United States |
PMID | 25565255
(Publication Type: Journal Article)
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Chemical References |
- 2-chloro-4-((2,5-dimethyl-1-(4-(trifluoromethoxy)phenyl)-1H-imidazol-4-yl)ethynyl)pyridine
- 2-chloro-4-(1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl)pyridine
- Imidazoles
- Pyridines
- Receptor, Metabotropic Glutamate 5
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Topics |
- Allosteric Regulation
(drug effects)
- Animals
- Depression
(drug therapy)
- Dose-Response Relationship, Drug
- Drug Discovery
- Fragile X Syndrome
(drug therapy)
- Humans
- Imidazoles
(chemical synthesis, chemistry, pharmacology)
- Macaca mulatta
- Male
- Mice
- Mice, Inbred Strains
- Molecular Structure
- Pyridines
(chemical synthesis, chemistry, pharmacology)
- Rats
- Rats, Sprague-Dawley
- Rats, Wistar
- Receptor, Metabotropic Glutamate 5
(antagonists & inhibitors)
- Structure-Activity Relationship
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