Genome mining offers a new starting point for parasitology research.

Abstract

Parasites including helminthes, protozoa, and medical arthropod vectors are a major cause of global infectious diseases, affecting one-sixth of the world's population, which are responsible for enormous levels of morbidity and mortality important and remain impediments to economic development especially in tropical countries. Prevalent drug resistance, lack of highly effective and practical vaccines, as well as specific and sensitive diagnostic markers are proving to be challenging problems in parasitic disease control in most parts of the world. The impressive progress recently made in genome-wide analysis of parasites of medical importance, including trematodes of Clonorchis sinensis, Opisthorchis viverrini, Schistosoma haematobium, S. japonicum, and S. mansoni; nematodes of Brugia malayi, Loa loa, Necator americanus, Trichinella spiralis, and Trichuris suis; cestodes of Echinococcus granulosus, E. multilocularis, and Taenia solium; protozoa of Babesia bovis, B. microti, Cryptosporidium hominis, Eimeria falciformis, E. histolytica, Giardia intestinalis, Leishmania braziliensis, L. donovani, L. major, Plasmodium falciparum, P. vivax, Trichomonas vaginalis, Trypanosoma brucei and T. cruzi; and medical arthropod vectors of Aedes aegypti, Anopheles darlingi, A. sinensis, and Culex quinquefasciatus, have been systematically covered in this review for a comprehensive understanding of the genetic information contained in nuclear, mitochondrial, kinetoplast, plastid, or endosymbiotic bacterial genomes of parasites, further valuable insight into parasite-host interactions and development of promising novel drug and vaccine candidates and preferable diagnostic tools, thereby underpinning the prevention and control of parasitic diseases.

• Authors: Zhiyue Lv, Zhongdao Wu, Limei Zhang, Pengyu Ji, Yifeng Cai, Shiqi Luo, Hongxi Wang, Hao Li
• Journal: Parasitology research (Parasitol Res) Vol. 114 Issue 2 Pg. 399-409 (Feb 2015) ISSN: 1432-1955 [Electronic] Germany
• PMID: 25563615 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Vaccines

Topics

• Animals
• Arthropod Vectors (genetics, immunology)
• Genomics
• Helminths (genetics, immunology)
• Host-Parasite Interactions
• Humans
• Parasites (genetics, immunology)
• Parasitic Diseases (diagnosis, parasitology, prevention & control)
• Plasmodium falciparum (genetics, immunology)
• Vaccines