HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Blood cell exchange in the treatment of exercise-induced rhabdomyolysis in a patient with sickle cell trait.

Abstract
We report the use of red blood cell exchange (RBCex) to treat rhabdomyolysis complicated by acute kidney injury in a 16-year-old African-American female with sickle cell trait (SCT). Treatment with aggressive fluid and electrolyte management failed to stem the rise in her creatine kinase, and RBCex was instituted 27 hours after symptom onset. She had a transient improvement in her creatine kinase following this treatment although it failed to resolve a developing lower extremity compartment syndrome, requiring bilateral lower extremity fasciotomies. The mechanism of exercise-induced rhabdomyolysis in individuals with SCT is theorized to result from localized hypoxia and acidosis within exercising muscle significant enough to cause a localized sickling crisis with resultant rhabdomyolysis. Despite the unique pathophysiology of rhabdomyolysis in individuals with SCT, there is a paucity of adjunctive treatment options beyond fluid and electrolyte therapy. To the best of our knowledge, RBCex for treatment of rhabdomyolysis in a patient with SCT has been described only once before by Huang et al. We report here a second case in the use of RBCex in the treatment of rhadbomyolysis in a patient with SCT.
AuthorsMichael F Papacostas, Matthew McLean
JournalMilitary medicine (Mil Med) Vol. 180 Issue 1 Pg. e145-8 (Jan 2015) ISSN: 1930-613X [Electronic] England
PMID25562874 (Publication Type: Journal Article)
CopyrightReprint & Copyright © 2015 Association of Military Surgeons of the U.S.
Chemical References
  • Creatine Kinase
Topics
  • Adolescent
  • Creatine Kinase (blood)
  • Erythrocyte Transfusion
  • Female
  • Humans
  • Plasmapheresis
  • Rhabdomyolysis (etiology, therapy)
  • Sickle Cell Trait (complications)
  • Track and Field

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: