Treatment of widespread
actinic keratoses (AKs) and extensive photodamage is a challenge. One of the treatment options is
laser therapy, whereby physicians have the option of using ablative
lasers (CO2 and
Erbium Yttrium Aluminium Garnet) or nonablative fractional
laser systems. With ablative
laser systems, the superficial layers of the skin are ablated, including epidermal and superficial dermal actinic damage. Re-epithelialization occurs from uninvolved skin and keratinocytes from follicles. When using a
CO2 laser, additional cosmetic improvements are a result of removal and tightening of the photodamaged
collagen in the superficial dermis. The most important risks of this treatment are
scarring and dyspigmentation. These risks are lessened when using fractional
lasers, which produce small columns of ablation or coagulation in the skin, leaving the surrounding skin intact. This treatment may be combined with topical agents. Existing evidence suggests that both ablative
laser resurfacing and fractional
laser treatments are effective in reducing AKs and photodamage. Although these treatment modalities are widely used and clinical experiences are positive, large comparative studies are remarkably scarce. Still,
laser resurfacing has a place in the (field) treatment of widespread AKs and extensive photodamage.