Dezocine prevents sufentanil-induced cough during general anesthesia induction: A randomized controlled trial.

Abstract

BACKGROUND:

Opioid-induced cough during induction of general anesthesia is a common phenomenon. Dezocine, a partial μ-receptors agonist and κ-receptors antagonist, has been documented effectively suppressing fentanyl-induced cough in general anesthesia induction. However, the effect of dezocine on sufentanil-induced cough is still unknown.

METHODS:

A total of 370 patients (American Society of Anesthesiologists physical status I-II), aged 18-70 years, undergoing elective surgery, were randomly divided into a control group (group C) and a dezocine group (group D) (n=185 in each group). Patients received dezocine 0.1mg/kg or an equal volume of 0.9% normal saline 2 min prior to intravenous sufentanil (0.5 μg/kg). The incidence and reflex degree of cough in patients were evaluated within 2 min after the injection of sufentanil in anesthesia induction period.

RESULTS:

No patient in group D had cough and 59 patients in group C had cough (severity of cough: mild, 7%; moderate, 11.4%; severe, 13.5%). The occurrence and reflex degree of cough in group D was significantly lower than that in group C (P=0.000). The highest heart rate (HR) and invasive blood pressure (IBP) values were higher in group C than those in group D (P<0.01) within 2 min after sufentanil administration, althought these values remained within safe limits.

CONCLUSION:

The results of current study suggest that administration of Dezocine 0.1mg/kg may effectively prevent the occurrence and reflex degree of sufentanil-induced irritating cough in general anesthesia induction in patients.

• Authors: Xue-Sheng Liu, Guang-Hong Xu, Qi-Ying Shen, Qing Zhao, Xin-Qi Cheng, Jian Zhang, Er-Wei Gu
• Journal: Pharmacological reports : PR (Pharmacol Rep) Vol. 67 Issue 1 Pg. 52-5 (Feb 2015) ISSN: 2299-5684 [Electronic] Switzerland
• PMID: 25560575 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Chemical References

• Analgesics, Opioid
• Anesthetics, Intravenous
• Bridged Bicyclo Compounds, Heterocyclic
• Tetrahydronaphthalenes
• Sufentanil
• dezocine

Topics

• Adolescent
• Adult
• Aged
• Analgesics, Opioid (therapeutic use)
• Anesthesia, General (adverse effects)
• Anesthetics, Intravenous (adverse effects)
• Blood Pressure (drug effects)
• Bridged Bicyclo Compounds, Heterocyclic (therapeutic use)
• Cough (chemically induced, prevention & control)
• Female
• Heart Rate (drug effects)
• Humans
• Incidence
• Male
• Middle Aged
• Reflex (drug effects)
• Sufentanil (adverse effects)
• Tetrahydronaphthalenes (therapeutic use)
• Young Adult