Revisiting the role of histo-blood group antigens in rotavirus host-cell invasion.

Abstract

Histo-blood group antigens (HBGAs) have been proposed as rotavirus receptors. H type-1 and Lewis(b) antigens have been reported to bind VP8* from major human rotavirus genotypes P[4], P[6] and P[8], while VP8* from a rarer P[14] rotavirus recognizes A-type HBGAs. However, the role and significance of HBGA receptors in rotavirus pathogenesis remains uncertain. Here we report that P[14] rotavirus HAL1166 and the related P[9] human rotavirus K8 bind to A-type HBGAs, although neither virus engages the HBGA-specific α1,2-linked fucose moiety. Notably, human rotaviruses DS-1 (P[4]) and RV-3 (P[6]) also use A-type HBGAs for infection, with fucose involvement. However, human P[8] rotavirus Wa does not recognize A-type HBGAs. Furthermore, the common human rotaviruses that we have investigated do not use Lewis(b) and H type-1 antigens. Our results indicate that A-type HBGAs are receptors for human rotaviruses, although rotavirus strains vary in their ability to recognize these antigens.

• Authors: Raphael Böhm, Fiona E Fleming, Andrea Maggioni, Vi T Dang, Gavan Holloway, Barbara S Coulson, Mark von Itzstein, Thomas Haselhorst
• Journal: Nature communications (Nat Commun) Vol. 6 Pg. 5907 (Jan 05 2015) ISSN: 2041-1723 [Electronic] England
• PMID: 25556995 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• ABO Blood-Group System
• Oligosaccharides

Topics

• ABO Blood-Group System (metabolism)
• Humans
• Magnetic Resonance Spectroscopy
• Molecular Dynamics Simulation
• Molecular Structure
• Oligosaccharides (chemistry, metabolism)
• Rotavirus (metabolism)
• Rotavirus Infections (metabolism, physiopathology)
• Virus Internalization