Protein tyrosine phosphatases in pathological process.

Abstract

Protein tyrosine phosphatases (PTPs) modulate the cellular level of tyrosine phosphorylation under normal and pathological conditions, and thus exert either stimulatory or inhibitory effect on signal transduction. Hence, PTPs are potential pharmacological targets for novel drugs being developed in order to treat numerous pathologies including cancer. For example, PTPs have been found to play a key role in pathogenesis of autoimmune disorders, allergic response, cardiovascular or neurodegenerative diseases, among others Alzheimer\'s disease. Moreover, since many PTPs fine-tune subtle regulation of microbial biochemistry controlling the viability and virulence, they can be candidates for new therapies of infection diseases. In this review, authors summarize the current knowledge on PTPs implication in etiopathogenesis of most common human diseases focusing on PTPs as potential therapeutical targets.

• Authors: Alicja Kuban-Jankowska, Magdalena Gorska, Narcyz Knap, Francesco Cappello, Michal Wozniak
• Journal: Frontiers in bioscience (Landmark edition) (Front Biosci (Landmark Ed)) Vol. 20 Issue 2 Pg. 377-88 (01 01 2015) ISSN: 2768-6698 [Electronic] Singapore
• PMID: 25553456 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Enzyme Inhibitors
• Protein Tyrosine Phosphatases

Topics

• Bacteria (pathogenicity)
• Carcinogenesis
• Enzyme Inhibitors (pharmacology)
• Humans
• Phosphorylation
• Protein Tyrosine Phosphatases (antagonists & inhibitors, metabolism)