Abstract | BACKGROUND: METHODS AND RESULTS: We enrolled 55 patients who underwent percutaneous coronary intervention for acute STEMI. Plasma CyPA, matrix metalloproteinase ( MMP), interleukin-6 and high-sensitivity C-reactive protein concentrations were measured at baseline and at one-month follow-up. Echocardiography was performed at baseline and at one-, three-, and six-month follow-up. Patients with a decrease in baseline CyPA concentration at one-month follow-up (n = 28) had a significant increase in LV ejection fraction (LVEF) (from 60.2 ± 11.5% to 64.6 ± 9.9%, p < 0. 001) and preserved LV synchrony at six months. Patients without a decrease in CyPA concentration at one month (n = 27) did not show improvement in LVEF and had a significantly increased systolic dyssynchrony index (SDI) (from 1.170 ± 0.510% to 1.637 ± 1.299%, p = 0.042) at six months. Multiple linear regression analysis showed a significant association between one-month CyPA concentration and six-month LVEF. The one-month MMP-2 concentration was positively correlated with one-month CyPA concentration and LV SDI. Conclusions : Decreased CyPA concentration at one-month follow-up after STEMI was associated with better LVEF and SDI at six months. Changes in CyPA, therefore, may be a prognosticator of patient outcome.
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Authors | Ching-Hui Huang, Chia-Chu Chang, Chen-Ling Kuo, Ching-Shan Huang, Chih-Sheng Lin, Chin-San Liu |
Journal | International journal of biological sciences
(Int J Biol Sci)
Vol. 11
Issue 1
Pg. 38-47
( 2015)
ISSN: 1449-2288 [Electronic] Australia |
PMID | 25552928
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Interleukin-6
- C-Reactive Protein
- Matrix Metalloproteinases
- Cyclophilin A
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Topics |
- Area Under Curve
- C-Reactive Protein
(metabolism)
- Cyclophilin A
(blood)
- Echocardiography
- Humans
- Interleukin-6
(blood)
- Matrix Metalloproteinases
(blood)
- Myocardial Infarction
(blood, therapy)
- Percutaneous Coronary Intervention
(methods)
- Pilot Projects
- Prognosis
- Prospective Studies
- Taiwan
- Time Factors
- Ventricular Function, Left
(physiology)
- Ventricular Remodeling
(physiology)
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