Abstract | BACKGROUND: Congenital ion channel disorders, including congenital long QT syndrome (LQTS), cause significant morbidity in pediatric patients. When medication therapy does not control symptoms or arrhythmias, more invasive treatment strategies may be necessary. This study examines our institution's clinical experience with surgical cardiac denervation therapy for management of these arrhythmogenic disorders in children. METHODS: RESULTS: Six of the ten patients had documented ventricular arrhythmias preoperatively, and 70% of the patients had preoperative syncope. The corrected QT interval decreased in 75% of patients with LQTS following sympathectomy. Postoperative arrhythmogenic symptoms were absent in 88% of congenital LQTS patients, but both patients with CPVT continued to have symptoms throughout the duration of follow-up. All patients were alive after a median follow-up period of 10 months. CONCLUSIONS:
|
Authors | John P Costello, Jennifer K Wilson, Clauden Louis, Syed M Peer, David Zurakowski, Evan P Nadler, Faisal G Qureshi, Richard A Jonas, E Anne Greene, Charles I Berul, Jeffrey P Moak, Dilip S Nath |
Journal | World journal for pediatric & congenital heart surgery
(World J Pediatr Congenit Heart Surg)
Vol. 6
Issue 1
Pg. 33-8
(Jan 2015)
ISSN: 2150-136X [Electronic] United States |
PMID | 25548341
(Publication Type: Evaluation Study, Journal Article)
|
Copyright | © The Author(s) 2014. |
Topics |
- Adolescent
- Channelopathies
(congenital, surgery)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Long QT Syndrome
(surgery)
- Male
- Retrospective Studies
- Stellate Ganglion
(surgery)
- Sympathectomy
- Tachycardia, Ventricular
(congenital, surgery)
- Thoracic Surgery, Video-Assisted
- Treatment Outcome
|