[Protective effects of m-nisoldipine and nisoldipine on myocardial damage in working rabbit hearts after ischemia-reperfusion].

Abstract

m-Nisoldipine 4, 8, 16 nmol/L, nisoldipine 1, 4 nmol/L and nifedipine 4, 8, 16, 50 nmol/L enhanced the recoveries of functional parameters of working rabbit hearts after ischemia-reperfusion, as well as prevented the development of contracture and the release of CPK from the reperfused hearts. m-Nisoldipine 8 nmol/L, nisoldipine 1 nmol/L and nifedipine 8 nmol/L attenuated the reduction of myocardial Na+-K+-ATPase and 5'-nucleotidase activity induced by ischemia-reperfusion. The breakdown of membrane phospholipids and elevation of the myocardial Ca2+-ATPase activity and the free fatty acids level were also prevented.

• Authors: H L Zhang, S X Fu, Y S Li
• Journal: Zhongguo yao li xue bao = Acta pharmacologica Sinica (Zhongguo Yao Li Xue Bao) Vol. 10 Issue 1 Pg. 49-53 (Jan 1989) ISSN: 0253-9756 [Print] China
• PMID: 2554666 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• Nisoldipine
• Creatine Kinase
• Sodium-Potassium-Exchanging ATPase
• Nifedipine

Topics

• Animals
• Calcium Channel Blockers
• Creatine Kinase (blood)
• Female
• In Vitro Techniques
• Isomerism
• Male
• Myocardial Reperfusion Injury (prevention & control)
• Myocardium (metabolism)
• Nifedipine (therapeutic use)
• Nisoldipine (therapeutic use)
• Rabbits
• Sodium-Potassium-Exchanging ATPase (metabolism)