[Solid pseudopapillary tumors of the pancreas: clinical and morphological characteristics, specific features of their immunophenotype, and diagnostic problems].

Abstract

OBJECTIVE:

To analyze 60 cases of solid pseudopapillary tumors (SPTs) of the pancreas, to reveal their most characteristic clinical and morphological features, and to study their possible histogenesis.

MATERIAL AND METHODS:

Sixty cases of SPTs of the pancreas underwent clinical, morphological, and immunohistochemical (IHC) examinations; a comparison group consisted of 86 pancreatic tumors of other histogenesis.

RESULTS:

It has been shown for the first time that SPTs are characterized by the nuclear expression of claudin 3 and the cytoplasmic expression of claudin 7. It has been also ascertained that the aberrant perinuclear (dot-like) expression of CD99 is a unique feature of these tumors.

CONCLUSION:

SPTs of the pancreas are distinguished by a diversity of clinical manifestations and morphological features, but have a unique immunophenotype, which can differentiate them from other types of pancreatic tumors.

• Authors: L E Gurevich, I A Kazantseva, I N Sokolova, N A Korsakova, E I Kuzovleva, O A Chistiakova, Iu A Aver'ianova, A V Egorov, T A Britvin, A A Dolzhikov, V I Egorov
• Journal: Arkhiv patologii (Arkh Patol) 2014 Sep-Oct Vol. 76 Issue 5 Pg. 44-54 ISSN: 0004-1955 [Print] Russia (Federation)
• PMID: 25543408 (Publication Type: Journal Article)

Chemical References

• 12E7 Antigen
• Antigens, CD
• Biomarkers, Tumor
• CD99 protein, human
• CLDN3 protein, human
• CLDN7 protein, human
• Cell Adhesion Molecules
• Claudin-3
• Claudins

Topics

• 12E7 Antigen
• Adolescent
• Adult
• Aged
• Antigens, CD (biosynthesis)
• Biomarkers, Tumor (biosynthesis)
• Carcinoma, Papillary (genetics, pathology)
• Cell Adhesion Molecules (biosynthesis)
• Child
• Claudin-3 (biosynthesis)
• Claudins (biosynthesis)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Male
• Middle Aged
• Pancreatic Neoplasms (genetics, pathology)
• Pathology, Molecular