Abstract |
By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5/PEG nanocomposites. The resulting GO/BaGdF5/PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo. The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5/PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5/PEG and the following 808-nm laser irradiation (0.5 W/cm(2)). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5/PEG in mice after treatment. These results indicate potential application of GO/BaGdF5/PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.
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Authors | Hao Zhang, Huixia Wu, Jun Wang, Yan Yang, Dongmei Wu, Yingjian Zhang, Yang Zhang, Zhiguo Zhou, Shiping Yang |
Journal | Biomaterials
(Biomaterials)
Vol. 42
Pg. 66-77
(Feb 2015)
ISSN: 1878-5905 [Electronic] Netherlands |
PMID | 25542794
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2014 Elsevier Ltd. All rights reserved. |
Chemical References |
- Barium Compounds
- Oxides
- Solutions
- Barium
- Polyethylene Glycols
- Graphite
- Gadolinium
- Fluorides
|
Topics |
- Animals
- Barium
(pharmacology)
- Barium Compounds
(pharmacology)
- Cell Death
(drug effects)
- Fluorides
(pharmacology)
- Gadolinium
(pharmacology)
- Graphite
(pharmacology)
- HeLa Cells
- Humans
- Hyperthermia, Induced
- Magnetic Resonance Imaging
- Mice
- Mice, Nude
- Multimodal Imaging
- Nanocomposites
(chemistry, ultrastructure)
- Neoplasms
(pathology)
- Oxides
(pharmacology)
- Phototherapy
- Polyethylene Glycols
(chemistry)
- Solutions
- Spectroscopy, Fourier Transform Infrared
- Spectroscopy, Near-Infrared
- Tomography, X-Ray Computed
- X-Ray Diffraction
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