HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

N-Bridged 5,6-bicyclic pyridines: Recent applications in central nervous system disorders.

Abstract
The search for novel heterobicyclic compounds within the drug-like chemical space continues to be an area of interest in medicinal chemistry. Unsaturated N-bridgehead heterocycles are well represented in marketed drugs for a variety of therapeutic areas, and continue to play an important role in central nervous system (CNS) drug discovery programs. Examples of medicinal chemistry strategies that make use of N-bridged 5,6-bicyclic pyridines are discussed here in this Minireview, which covers the literature from 2010 up to 2014. B1-class imidazopyridines and B3-class pyrazolopyridines have proven to be at the forefront of molecular prototypes that are capable of interacting with disease relevant targets in neurodegeneration and neuropsychiatry.
AuthorsOscar Delgado, Francisca Delgado, Juan Antonio Vega, Andrés A Trabanco
JournalEuropean journal of medicinal chemistry (Eur J Med Chem) Vol. 97 Pg. 719-31 (Jun 05 2015) ISSN: 1768-3254 [Electronic] France
PMID25542766 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2014 Elsevier Masson SAS. All rights reserved.
Chemical References
  • Bridged Bicyclo Compounds, Heterocyclic
  • Pyridines
  • pyridine
Topics
  • Bridged Bicyclo Compounds, Heterocyclic (chemistry)
  • Central Nervous System Diseases (drug therapy)
  • Drug Discovery (methods)
  • Humans
  • Pyridines (chemistry, pharmacology, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: