Abstract |
The search for novel heterobicyclic compounds within the drug-like chemical space continues to be an area of interest in medicinal chemistry. Unsaturated N-bridgehead heterocycles are well represented in marketed drugs for a variety of therapeutic areas, and continue to play an important role in central nervous system (CNS) drug discovery programs. Examples of medicinal chemistry strategies that make use of N-bridged 5,6-bicyclic pyridines are discussed here in this Minireview, which covers the literature from 2010 up to 2014. B1-class imidazopyridines and B3-class pyrazolopyridines have proven to be at the forefront of molecular prototypes that are capable of interacting with disease relevant targets in neurodegeneration and neuropsychiatry.
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Authors | Oscar Delgado, Francisca Delgado, Juan Antonio Vega, Andrés A Trabanco |
Journal | European journal of medicinal chemistry
(Eur J Med Chem)
Vol. 97
Pg. 719-31
(Jun 05 2015)
ISSN: 1768-3254 [Electronic] France |
PMID | 25542766
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2014 Elsevier Masson SAS. All rights reserved. |
Chemical References |
- Bridged Bicyclo Compounds, Heterocyclic
- Pyridines
- pyridine
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Topics |
- Bridged Bicyclo Compounds, Heterocyclic
(chemistry)
- Central Nervous System Diseases
(drug therapy)
- Drug Discovery
(methods)
- Humans
- Pyridines
(chemistry, pharmacology, therapeutic use)
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