Giardia is the most common causes of protozoan
diarrhea that lead to significant morbidity and mortality worldwide.
Giardiasis can be cause of disturbance of host immune response. The treatment of
Giardiasis is unsuccessful in some cases. The purpose of this study was to determine the clinical features and the content of
secretory immunoglobulin A (
sIgA) among adults and to evaluate efficiency of new
plant preparation "Sausalin". The clinical studies were conducted in Karaganda Regional
Infection Hospital (Kazakhstan). 250 patients with
giardiasis were randomly assigned to receive sausalin at a dose 720 mg/day or
ornidazole at 1500 mg/day. Clinical symptoms of giardisis and efficiency of treatment were evaluated. Protozoal clearance rate and clinical symptoms were assessed. Stool samples were collected from 40 patients and examined the content of
sIgA. Our study found the prevalence of
abdominal pain, dyspeptic syndrome and the symptoms of intoxication in patients with
giardiasis. The increase the level of
sIgA was detected, especially in females (88 mg/l). Sausalin was more effectiveness than
ornidazole. After the treatment, the clearance rate of giardia (85.71% vs. 42.19%; P<0.05) and the clinical efficacy were significantly higher in the sausalin-treated group than in the
ornidazole-treated group. The features of clinic manifestations of
giardiasis were identified in population of Kazakhstan. Our data suggest the higher level of
sIgA was significantly associated with features of clinic manifestations that the participant had. Treatment with sausalin was more effective than treatment with
ornidazole. Further research is needed to explain the existence relationship between
Giardia infection and host immune response.