Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: a meta-analysis.

Abstract

PURPOSE:

This study was aimed to determine the relationship of alcohol-metabolizing enzymes ADH2, ADH3, and ALDH2 polymorphisms with the susceptibility to alcoholic chronic pancreatitis (ACP).

METHODS:

Meta-analyses that evaluated the association of ADH2, ADH3, and ALDH2 variations with ACP were performed.

RESULTS:

Eight case-control studies were selected for analysis. The overall data revealed a significant association of ADH2 polymorphism (OR=1.56, 95% CI=1.42-1.72, P=0.000 for dominant model; OR=1.63, 95% CI=1.55-1.71, P=0.000 for homozygote comparison model; OR=1.11, 95% CI=1.01-1.22, P=0.030 for allelic contrast model), ADH3 polymorphism (OR=0.95, 95% CI=0.86-1.06, P=0.389 for dominant; OR=0.64, 95% CI=0.44-0.93, P=0.020 for homozygote comparison; and OR=0.87, 95% CI=0.77-0.99, P=0.039 for allelic contrast model) and ALDH2 polymorphism (OR=0.57, 95% CI=0.40-0.81, P=0.002 for dominant; OR=0.50, 95% CI=0.23-1.08, P=0.079 for homozygote comparison; and OR=0.58, 95% CI=0.41-0.84, P=0.003 for allelic contrast model) with ACP risk. The subgroup analyses suggested that the variant ADH2*2/*2+*1/*2, ADH2*2/*2 genotype and ADH2*2 allele significantly increased ACP risk among Asian individuals; the variant ADH3*2/*2 genotype and ADH3*2 allele significantly decreased ACP risk among non-Asian individuals; and the variant ALDH2*2/*2+*1/*2 genotype and ALDH2*2 allele significantly decreased ACP risk among Asians.

CONCLUSIONS:

ADH2, ADH3 and ALDH2 polymorphisms may be susceptibility facts of ACP, and it may be ethnic and race-dependent.

• Authors: Yanjun Zhong, Jie Cao, Runmei Zou, Mou Peng
• Journal: Gastroenterologia y hepatologia (Gastroenterol Hepatol) 2015 Aug-Sep Vol. 38 Issue 7 Pg. 417-25 ISSN: 0210-5705 [Print] Spain
• PMID: 25541509 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2014 Elsevier España, S.L.U. and AEEH y AEG. All rights reserved.

Chemical References

• Ethanol
• ADH1B protein, human
• ADH1C protein, human
• Alcohol Dehydrogenase
• ALDH2 protein, human
• Aldehyde Dehydrogenase, Mitochondrial

Topics

• Alcohol Dehydrogenase (genetics)
• Aldehyde Dehydrogenase, Mitochondrial (genetics)
• Alleles
• Asian People (genetics)
• Case-Control Studies
• Ethanol (pharmacokinetics)
• Genetic Predisposition to Disease
• Genotype
• Humans
• Pancreatitis, Alcoholic (ethnology, genetics)
• Polymorphism, Genetic