Abstract | BACKGROUND: The purpose of this study was to investigate the cancer incidence in patients with end-stage aristolochic acid nephropathy (AAN). METHODS: RESULTS: The cancer incidence rate in our patients was 41.2% (42 in 102) including 39 cases of urinary cancer. The mortality rate in the patients with cancer was significantly higher than that in the patients without cancer (31%, 13/42 vs. 11.7%, 7/60, p<0.05). Thirteen patients developed cancer before entering end-stage renal disease ( ESRD). Cancer incidence was significantly associated with the dosage of AA consumption (p=0.091). Hemodialysis, peritoneal dialysis and renal transplant did not affect the cancer incidence in our patients differently, but appeared to be associated with cancer at particular locations of urinary system. The patients undergoing hemodialysis seemed to more likely have bladder cancer (72.72%), while the patients receiving peritoneal dialysis appeared to develop cancer predominantly in the upper urinary tract (66.67%). CONCLUSIONS: The cancer initiation in our patients seems significantly correlate with the dosage of AA consumption. Different renal replacement therapies appear to be associated with cancer at particular locations of urinary system in our patients.
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Authors | Mei Sun, Jianna Zhang, Chenfei Zheng, Yi Liu, Fan Lin, Feifei Xu, Chaosheng Chen |
Journal | Renal failure
(Ren Fail)
Vol. 37
Issue 2
Pg. 209-13
(Mar 2015)
ISSN: 1525-6049 [Electronic] England |
PMID | 25540870
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aristolochic Acids
- Carcinogens
- aristolochic acid I
- CYP1A1 protein, human
- Cytochrome P-450 CYP1A1
- NAD(P)H Dehydrogenase (Quinone)
- NQO1 protein, human
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Topics |
- Aged
- Aristolochic Acids
(adverse effects, pharmacokinetics)
- Carcinogens
(pharmacokinetics)
- China
(epidemiology)
- Cytochrome P-450 CYP1A1
(analysis)
- Female
- Hematologic Neoplasms
(diagnosis, epidemiology, etiology)
- Humans
- Incidence
- Kidney Failure, Chronic
(chemically induced, complications, mortality)
- Male
- Middle Aged
- NAD(P)H Dehydrogenase (Quinone)
(analysis)
- Renal Dialysis
(statistics & numerical data)
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Survival Analysis
- Urologic Neoplasms
(diagnosis, epidemiology, etiology)
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