Abstract | BACKGROUND: METHODS: The 50-g GCT was performed in 20 prevalent patients without history of diabetes before PD treatment onset, who had been on dialysis for a median time of 15.34 months. In addition, other indicators of glucose metabolism were measured: C-peptide, fasting insulin serum concentration, and the glycated hemoglobin level (HbA1c). The patients were prospectively followed for a median time of 25.8 months. RESULTS: 50-g GCT revealed GMD in 15 studied patients (75%)-- impaired glucose tolerance in 11 patients (55%) and diabetes mellitus in four patients (20%). HbA1c and insulin resistance, estimated by homeostasis model assessment, were elevated in two (10%) and seven (35%) patients, respectively. In patients with GMD, dietetic and pharmacologic interventions were performed. When the 50-g GCT was repeated at the end of the observation period, 12 (60%) patients reported GMD, with no case of diabetes. CONCLUSION: 50-g GCT appears to be a simple and practical tool for the detection of GMD in PD patients with normal fasting glucose. Timely therapeutic intervention can effectively inhibit the progression of glucose intolerance during PD treatment.
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Authors | Katarzyna Madziarska, Slawomir Zmonarski, Jozef Penar, Magdalena Krajewska, Oktawia Mazanowska, Hanna Augustyniak-Bartosik, Tomasz Gołebiowski, Renata Klak, Waclaw Weyde, Marian Klinger |
Journal | International urology and nephrology
(Int Urol Nephrol)
Vol. 47
Issue 4
Pg. 695-700
(Apr 2015)
ISSN: 1573-2584 [Electronic] Netherlands |
PMID | 25539618
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Blood Glucose
(metabolism)
- Fasting
(blood)
- Female
- Follow-Up Studies
- Glucose Metabolism Disorders
(blood, epidemiology, etiology)
- Glucose Tolerance Test
- Humans
- Kidney Failure, Chronic
(blood, therapy)
- Male
- Middle Aged
- Peritoneal Dialysis
(adverse effects)
- Poland
(epidemiology)
- Prevalence
- Retrospective Studies
- Risk Factors
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