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[Th1/2-balance shift during acute graft-versus-host reaction developing against the background of experimental hyperlipidemia].

AbstractAIM:
Evaluate the effect of experimental hyperlipidemia on the intensity of development of acute graft-versus-host reaction (GVHR) in mice.
MATERIALS AND METHODS:
Half-allogenic system C57Bl/6 (C57Bl/6 x DBA/2)F1 was used as a laboratory model of acute GVHR. Experimental hyperlipidemia in mice-recipients was induced by repeated administration of poloxamer 407.
RESULTS:
Lethality in the group of mice with acute GVHR developing against the background of preceding hyperlipidemia was significantly higher (70% at day 50 of GVHR development) compared with control group with acute GVHR (50% lethality at day 50). Such effect on the degree of severity of acute GVHR induced under the conditions of hyperlipidemia is confirmed by a more pronounced destruction of thymus in mice of the group with previously induced hyperlipidemia.
CONCLUSION:
Preceding hyperlipidemia induced by administration of poloxamer 407 shifts Th1/2- balance in the development of acute GVHR towards Th1. Mechanisms of this effect and possible role of nuclear LXR receptors in regulation of immune reactions are discussed.
AuthorsN N Volskiĭ, O M Perminova, O P Kolesnikova
JournalZhurnal mikrobiologii, epidemiologii i immunobiologii (Zh Mikrobiol Epidemiol Immunobiol) 2014 Sep-Oct Issue 5 Pg. 70-7 ISSN: 0372-9311 [Print] Russia (Federation)
PMID25536775 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Poloxamer
Topics
  • Animals
  • Cytotoxicity, Immunologic
  • Graft vs Host Reaction (immunology)
  • Humans
  • Hyperlipidemias (chemically induced, immunology, pathology)
  • Mice
  • Poloxamer (toxicity)
  • Spleen (immunology, pathology)
  • Th1-Th2 Balance
  • Thymus Gland (immunology, pathology)

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