Abstract | AIM: Evaluate the effect of experimental hyperlipidemia on the intensity of development of acute graft-versus-host reaction (GVHR) in mice. MATERIALS AND METHODS: Half-allogenic system C57Bl/6 (C57Bl/6 x DBA/2)F1 was used as a laboratory model of acute GVHR. Experimental hyperlipidemia in mice-recipients was induced by repeated administration of poloxamer 407. RESULTS: Lethality in the group of mice with acute GVHR developing against the background of preceding hyperlipidemia was significantly higher (70% at day 50 of GVHR development) compared with control group with acute GVHR (50% lethality at day 50). Such effect on the degree of severity of acute GVHR induced under the conditions of hyperlipidemia is confirmed by a more pronounced destruction of thymus in mice of the group with previously induced hyperlipidemia. CONCLUSION: Preceding hyperlipidemia induced by administration of poloxamer 407 shifts Th1/2- balance in the development of acute GVHR towards Th1. Mechanisms of this effect and possible role of nuclear LXR receptors in regulation of immune reactions are discussed.
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Authors | N N Volskiĭ, O M Perminova, O P Kolesnikova |
Journal | Zhurnal mikrobiologii, epidemiologii i immunobiologii
(Zh Mikrobiol Epidemiol Immunobiol)
2014 Sep-Oct
Issue 5
Pg. 70-7
ISSN: 0372-9311 [Print] Russia (Federation) |
PMID | 25536775
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Animals
- Cytotoxicity, Immunologic
- Graft vs Host Reaction
(immunology)
- Humans
- Hyperlipidemias
(chemically induced, immunology, pathology)
- Mice
- Poloxamer
(toxicity)
- Spleen
(immunology, pathology)
- Th1-Th2 Balance
- Thymus Gland
(immunology, pathology)
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